Journal ArticleDOI
Chronic glomerulonephritis associated with low serum complement activity (chronic hypocomplementemic glomerulonephritis).
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This article is published in Medicine.The article was published on 1970-05-01. It has received 82 citations till now.read more
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Book ChapterDOI
Immune Complex Disease in Experimental Animals and Man
Charles G. Cochrane,D Koffler +1 more
TL;DR: This chapter summarizes the data presented in two reviews of experimental acute and chronic immune complex disease produced by nonliving antigens and discusses in detail more recent studies.
Journal ArticleDOI
Evidence for Complement Activation via the Alternate Pathway in Skin Diseases I HERPES GESTATIONIS, SYSTEMIC LUPUS ERYTHEMATOSUS, AND BULLOUS PEMPHIGOID
TL;DR: Substantial evidence is provided that activation of complement is occurring via the alternate pathway in herpes gestationis and in systemic lupus erythematosus and bullous pemphigoid, both the classical (antibody) mediatedactivation of complement as well as the alternate pathways may be operative.
Journal ArticleDOI
Idiopathic mesangiocapillary glomerulonephritis: Comparison of types I and II in children and adults and long-term prognosis
J. Stewart Cameron,David R. Turner,Juliet M. Heaton,D. Gwyn Williams,Chisholm S. Ogg,Cyril Chantler,George B. Haycock,Jackie Hicks +7 more
TL;DR: Type II mesangiocapillary glomerulonephritis was more common in children than in adults, but no other clinical feature distinguished the two types at onset, and patients with type II had lower serum C3 concentrations and more frequently showed C3-splitting activity in the serum.
Journal ArticleDOI
Metabolic Studies of the Third Component of Complement and the Glycine-Rich Beta Glycoprotein in Patients with Hypocomplementemia
TL;DR: GBG turnover was normal or only slightly accelerated in some patients with accelerated C3 catabolism and profound hypocomplementemia, suggesting that reduced C3 synthesis had limited activation of the C3b-feedback.
Journal ArticleDOI
Mesangiocapillary nephritis, partial lipodystrophy, and hypocomplementaemia.
D.K. Peters,J. A. Charlesworth,J.G.P. Sissons,D. Gwyn Williams,J. M. Boulton-Jones,Denis J. Evans,O. Kourilsky,L. Morel-Maroger +7 more
TL;DR: Three patients with partial lipodystrophy, C3 activation and hypocomplementaemia, and mesangiocapillary glomerulonephritis of the dense-deposit variety are described and it is proposed that the primary abnormality in these and other patients with this type of nephritis is C3activation which results in prolonged hypocomplementationaemia.