Journal ArticleDOI
Chronic Health Conditions in Adult Survivors of Childhood Cancer
Kevin C. Oeffinger,Ann C. Mertens,Charles A. Sklar,Toana Kawashima,Melissa M. Hudson,Anna T. Meadows,Debra L. Friedman,Neyssa Marina,Wendy L. Hobbie,Nina S. Kadan-Lottick,Cindy L. Schwartz,Wendy M. Leisenring,Leslie L. Robison +12 more
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TLDR
Survivors of childhood cancer have a high rate of illness owing to chronic health conditions, including severe, disabling, or life-threatening conditions or death due to a chronic condition.Abstract:
Background Only a few small studies have assessed the long-term morbidity that follows the treatment of childhood cancer. We determined the incidence and severity of chronic health conditions in adult survivors. Methods The Childhood Cancer Survivor Study is a retrospective cohort study that tracks the health status of adults who received a diagnosis of childhood cancer between 1970 and 1986 and compares the results with those of siblings. We calculated the frequencies of chronic conditions in 10,397 survivors and 3034 siblings. A severity score (grades 1 through 4, ranging from mild to life-threatening or disabling) was assigned to each condition. Cox proportional-hazards models were used to estimate hazard ratios, reported as relative risks and 95% confidence intervals (CIs), for a chronic condition. Results Survivors and siblings had mean ages of 26.6 years (range, 18.0 to 48.0) and 29.2 years (range, 18.0 to 56.0), respectively, at the time of the study. Among 10,397 survivors, 62.3% had at least one chronic condition; 27.5% had a severe or life-threatening condition (grade 3 or 4). The adjusted relative risk of a chronic condition in a survivor, as compared with siblings, was 3.3 (95% CI, 3.0 to 3.5); for a severe or life-threatening condition, the risk was 8.2 (95% CI, 6.9 to 9.7). Among survivors, the cumulative incidence of a chronic health condition reached 73.4% (95% CI, 69.0 to 77.9) 30 years after the cancer diagnosis, with a cumulative incidence of 42.4% (95% CI, 33.7 to 51.2) for severe, disabling, or life-threatening conditions or death due to a chronic condition. Conclusions Survivors of childhood cancer have a high rate of illness owing to chronic health conditions.read more
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Cancer treatment and survivorship statistics, 2012
Rebecca L. Siegel,Carol DeSantis,Katherine S. Virgo,Kevin Stein,Angela B. Mariotto,Tenbroeck Smith,Dexter L. Cooper,Ted Gansler,Catherine C. Lerro,Stacey A. Fedewa,Chun Chieh Lin,Corinne R. Leach,Rachel S. Cannady,Hyunsoon Cho,Steve Scoppa,Mark Hachey,Rebecca A. Kirch,Ahmedin Jemal,Elizabeth Ward +18 more
TL;DR: Common cancer treatments, survival rates, and posttreatment concerns are summarized and the new National Cancer Survivorship Resource Center is introduced, which has engaged more than 100 volunteer survivorship experts nationwide to develop tools for cancer survivors, caregivers, health care professionals, advocates, and policy makers.
Journal ArticleDOI
2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines
José Luis Zamorano,Patrizio Lancellotti,Daniel Rodriguez Muñoz,Victor Aboyans,Riccardo Asteggiano,Maurizio Galderisi,Gilbert Habib,Daniel J. Lenihan,Gregory Y.H. Lip,Alexander R. Lyon,Teresa López Fernández,Dania Mohty,Massimo F. Piepoli,Juan Tamargo,Adam Torbicki,Thomas M. Suter +15 more
TL;DR: This document describes the development and use of angiotensin-converting enzyme, a non-volatile substance that acts as a “spatially aggregating substance” to reduce the chances of heart attack in women.
Journal ArticleDOI
2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)
José Luis Zamorano,Patrizio Lancellotti,Daniel Rodriguez Muñoz,Victor Aboyans,Riccardo Asteggiano,Maurizio Galderisi,Gilbert Habib,Daniel J. Lenihan,Gregory Y.H. Lip,Alexander R. Lyon,Teresa López Fernández,Dania Mohty,Massimo F. Piepoli,Juan Tamargo,Adam Torbicki,Thomas M. Suter,Stephan Achenbach,Stefan Agewall,Lina Badimon,Gonzalo Barón-Esquivias,Helmut Baumgartner,Jeroen J. Bax,Héctor Bueno,Scipione Carerj,Veronica Dean,Çetin Erol,Donna Fitzsimons,Oliver Gaemperli,Paulus Kirchhof,Philippe Kolh,Petros Nihoyannopoulos,Piotr Ponikowski,Marco Roffi,Antonio Vaz Carneiro,Stephan Windecker +34 more
TL;DR: No abstract available Keywords: European Society of Cardiology; arrhythmias; cancer therapy; cardio-oncology; cardiotoxicity; chemotherapy; early detection; ischaemia; myocardial dysfunction; surveillance.
Journal ArticleDOI
Acute Lymphoblastic Leukemia in Children
TL;DR: The most common cancer in childhood is now curable in 90% of patients and the subsets of acute lymphoblastic leukemia that are most resistant to current therapy are being targeted.
Journal ArticleDOI
Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management.
TL;DR: The incidence of cardiotoxicity caused by commonly used chemotherapeutic agents as well as the pathogenesis, diagnosis, management, and prevention of these cardiovascular side effects are reviewed.
References
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Modeling Survival Data: Extending the Cox Model
TL;DR: A Cox Model-based approach was used to estimate the Survival and Hazard Functions and the results confirmed the need for further investigation into the role of natural disasters in shaping survival rates.
Journal ArticleDOI
Estimation of failure probabilities in the presence of competing risks: new representations of old estimators
Ted Gooley,Ted Gooley,Wendy M. Leisenring,Wendy M. Leisenring,John Crowley,John Crowley,Barry E. Storer,Barry E. Storer +7 more
TL;DR: A representation of each estimate in a manner not ordinarily seen is presented, each representation utilizing the concept of censored observations being 'redistributed to the right' to allow a more intuitive understanding of each estimates.
Journal ArticleDOI
Health Status of Adult Long-term Survivors of Childhood Cancer A Report From the Childhood Cancer Survivor Study
Melissa M. Hudson,Ann C. Mertens,Yutaka Yasui,Wendy L. Hobbie,Hegang Chen,James G. Gurney,Mark W. Yeazel,Christopher J. Recklitis,Neyssa Marina,Leslie R. Robison,Kevin C. Oeffinger +10 more
TL;DR: Clinicians caring for adult survivors of childhood cancer should be aware of the substantial risk for adverse health status, especially among females, those withLow educational attainment, and those with low household incomes.
Journal ArticleDOI
Late mortality experience in five-year survivors of childhood and adolescent cancer: The Childhood Cancer Survivor Study
Ann C. Mertens,Yutaka Yasui,Joseph P. Neglia,John D. Potter,Mark E. Nesbit,Kathy Ruccione,W. Anthony Smithson,Leslie L. Robison +7 more
TL;DR: While recurrent disease remains a major contributor to late mortality in 5-year survivors of childhood cancer, significant excesses in mortality risk associated with treatment-related complications exist up to 25 years after the initial cancer diagnosis.
Journal ArticleDOI
Female sex and higher drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer.
Steven E. Lipshultz,Lipsitz,Suzanne M. Mone,Allen M. Goorin,Stephen E. Sallan,Stephen P. Sanders,Endel J. Orav,Richard D. Gelber,Steven D. Colan +8 more
TL;DR: Female sex and a higher rate of administration of doxorubicin were independent risk factors for cardiac abnormalities after treatment with doxorbicin for childhood cancer; the prevalence and severity of abnormalities increased with longer follow-up.