Journal ArticleDOI
Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).
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TLDR
This classification of the different platelet concentrates into four categories, depending on their leucocyte and fibrin content, should help to elucidate successes and failures that have occurred so far, as well as providing an objective approach for the further development of these techniques.About:
This article is published in Trends in Biotechnology.The article was published on 2009-03-01. It has received 1454 citations till now. The article focuses on the topics: Platelet-rich fibrin & Platelet-rich plasma.read more
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Journal ArticleDOI
Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial.
Robert J. de Vos,Adam Weir,Hans T. M. van Schie,Sita M A Bierma-Zeinstra,Jan A N Verhaar,Harrie Weinans,Johannes L. Tol +6 more
TL;DR: Among patients with chronic Achilles tendinopathy who were treated with eccentric exercises, a PRP injection compared with a saline injection did not result in greater improvement in pain and activity, and was not significantly different between both groups.
Journal ArticleDOI
Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective.
Dhurat R,M. S. Sukesh +1 more
TL;DR: The principles and preparation methods of PRP are reviewed based on available literature and a perspective in standardizing a safe, simple protocol that can be followed to obtain an optimal consistent platelet yield is placed.
Journal ArticleDOI
The Role of Growth Factors in Cartilage Repair
TL;DR: The application of growth factors in the treatment of local cartilage defects as well as osteoarthritis appears promising; however, further research is needed at both the basic science and clinical levels before routine application.
Journal ArticleDOI
Ongoing Positive Effect of Platelet-Rich Plasma Versus Corticosteroid Injection in Lateral Epicondylitis: A Double-Blind Randomized Controlled Trial With 2-year Follow-up
TL;DR: Treatment of patients with chronic lateral epicondylitis with PRP reduces pain and increases function significantly, exceeding the effect of corticosteroid injection even after a follow-up of 2 years.
Journal ArticleDOI
Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane.
David M. Dohan Ehrenfest,Marco Del Corso,Antoine Diss,Jaafar Mouhyi,Jaafar Mouhyi,Jean-Baptiste Charrier +5 more
TL;DR: The PRF protocol concentrated most platelets and leukocytes from a blood harvest into a single autologous fibrin biomaterial and offers reproducible results as long as the main production principles are respected.
References
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Platelet-rich plasma: Growth factor enhancement for bone grafts
Robert E. Marx,Eric R. Carlson,Ralph M. Eichstaedt,Ralph M. Eichstaedt,Steven R Schimmele,Steven R Schimmele,James E. Strauss,Karen R. Georgeff +7 more
TL;DR: Monoclonal antibody assessment of cancellous cellular marrow grafts demonstrated cells that were capable of responding to the growth factors by bearing cell membrane receptors and evidenced a radiographic maturation rate 1.62 to 2.16 times that of grafts without platelet-rich plasma.
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Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution.
D. Dohan,Joseph Choukroun,Antoine Diss,Steve L. Dohan,Anthony Dohan,Jaafar Mouhyi,Bruno Gogly +6 more
TL;DR: A retrospective analysis is necessary for the understanding of fibrin technologies and the evaluation of the biochemical properties of 3 generations of surgical additives, respectively fibr in adhesives, concentrated platelet-rich plasma (cPRP) and PRF.
Journal Article
Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants.
TL;DR: Preliminary clinical evidence is presented of the beneficial effect of the use of plasma rich in growth factors of autologous origin, which can introduce several advantages, including the enhancement and acceleration of bone regeneration and more rapid and predictable soft tissue healing.
Journal ArticleDOI
Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features.
D. Dohan,Joseph Choukroun,Antoine Diss,Steve L. Dohan,Anthony Dohan,Jaafar Mouhyi,Bruno Gogly +6 more
TL;DR: Initial analyses revealed that slow fibrin polymerization during PRF processing leads to the intrinsic incorporation of platelet cytokines and glycanic chains in the fibrIn meshes, which would imply that PRF, unlike the other platelet concentrates, would be able to progressively release cytokines during fibr in matrix remodeling; such a mechanism might explain the clinically observed healing properties of PRF.
Journal ArticleDOI
Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing
Joseph Choukroun,Antoine Diss,Alain Simonpieri,Marie-Odile Girard,Christian Schoeffler,Steve L. Dohan,Anthony Dohan,Jaafar Mouhyi,D. Dohan +8 more
TL;DR: Investigation is made into the previously evaluated biology of PRF with the first established clinical results, to determine the potential fields of application for this biomaterial and to plan several future PRF applications, including plastic and bone surgery.