Open AccessJournal Article
Clomipramine in the treatment of patients with obsessive-compulsive disorder
Joseph DeVeaugh-Geiss,Richard J. Katz,P. Landau,Hagop S. Akiskal,Jambur Ananth,James C. Ballenger,Wilmer C. Betts,Bruce I. Diamond,Alan Feiger,Edna B. Foa,David Fogelson,Wayne K. Goodman,John H. Greist,Jonathan M. Himmelhoch,Rudolf Hoehn-Saric,Michael A. Jenike,Suck Won Kim,Michael R. Liebowitz,Matig Mavissakalian,Philip T. Ninan,Russell Noyes,Steven A. Rasmussen,Alan Ringold,Katherine Shear +23 more
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TLDR
Clomipramine was generally well tolerated and was effective in reducing obsessive and compulsive symptoms and was superior on the basis of the physicians' and patients' evaluations of global therapeutic change.Abstract:
Two double-blind studies at 21 centers evaluated the therapeutic efficacy, safety, and tolerability of up to 300 mg/d of clomipramine hydrochloride or an equivalent number of placebo capsules in the treatment of 520 patients with obsessive-compulsive disorder, of whom 239 had had the disorder for at least 2 years (study 1) and 281 had been ill for at least 1 year (study 2). On the two principal measures of the severity of the disorder, ie, the Yale-Brown Obsessive Compulsive Scale and the National Institute of Mental Health Global Obsessive Compulsive Scale, clomipramine was significantly more effective than placebo in both studies. The mean reduction in the Yale-Brown Obsessive Compulsive Scale score at the end of 10 weeks of treatment was 38% and 44% in studies 1 and 2, respectively, for the clomipramine-treated patients and 3% and 5% for the placebo-treated patients. The drug was also found to be superior on the basis of the physicians' and patients' evaluations of global therapeutic change. The most frequently observed adverse effects during clomipramine therapy were those typically associated with tricyclic antidepressant drugs. Although uncommon, the occurrence of seizures and elevated aminotransferase values are potentially serious side effects of clomipramine. Clomipramine was generally well tolerated and was effective in reducing obsessive and compulsive symptoms.read more
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The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency
Suck Won Kim,Maurice W. Dysken,Alfred M. Pheley,Alfred M. Pheley,Kathleen Maxwell Hoover,Kathleen Maxwell Hoover +5 more
TL;DR: Examination of the postreatment factor scores showed that the Y-BOCS resistance items did not assess OCD symptom change as sensitively as the rest of the Y, Brown Obsessive-Compulsive Scale items did.
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On stigma and its consequences: evidence from a longitudinal study of men with dual diagnoses of mental illness and substance abuse.
TL;DR: This finding indicates that stigma continues to complicate the lives of the stigmatized even as treatment improves their symptoms and functioning, and it follows that if health professionals want to maximize the well-being of the people they treat, they must address stigma as a separate and important factor in its own right.
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Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder.
Lewis R. Baxter,Jeffrey M. Schwartz,Kenneth S. Bergman,Martin P. Szuba,Barry H. Guze,John C. Mazziotta,Adina Alazraki,Carl Selin,Huan-Kwang Ferng,Paul Munford,Michael E. Phelps +10 more
TL;DR: Right orbital cortex/hem was significantly correlated with ipsilateral Cd/hem and thalamus/hem before treatment but not after, and the differences before and after treatment were significant, suggesting a brain circuit involving these brain regions may mediate obsessive-compulsive disorder symptoms.
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Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder.
Edna B. Foa,Michael R. Liebowitz,Michael J. Kozak,Sharon Davies,Rafael Campeas,Martin E. Franklin,Jonathan D. Huppert,Kevin Kjernisted,Vivienne Rowan,Andrew B. Schmidt,H. Blair Simpson,Xin Tu +11 more
TL;DR: Intensive exposure and ritual prevention may be superior to clomipramine and, by implication, to monotherapy with the other SRIs and their combination are all efficacious treatments for OCD.