Journal ArticleDOI
Co-operativity and calcium/magnesium binding to troponin C and muscle calcium binding parvalbumin: An hypothesis
R E Reid,Robert S. Hodges +1 more
TLDR
Through the use of a single site model and a two site co-operative model, the differences in amino acid sequence of the various loop regions of the helix-loop-helix arrangement are correlated with experimentally determined affinities for calcium and magnesium as well as predict the relative cation affinITIES of loop regions from the amino acid sequences.About:
This article is published in Journal of Theoretical Biology.The article was published on 1980-06-07. It has received 90 citations till now. The article focuses on the topics: Calcium & Cation binding.read more
Citations
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Journal ArticleDOI
Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs
TL;DR: A structural approach is used in this review to examine the diversity of family members, and a biophysical perspective provides insight into the ability of the EF-hand motif to bind Ca2+ with a wide range of affinities.
Journal ArticleDOI
Thin filament proteins and thin filament-linked regulation of vertebrate muscle contraction.
TL;DR: The relation of protein structure to function will be emphasized and the relation of various physiologically and histochemically defined fiber types to the proteins found in them will be discussed.
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Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes. Theoretical approach to study of multiple ligand binding to a macromolecule
TL;DR: The ordered binding properties support the suggestion that calmodulin translates quantitative Ca2+ signals into qualitatively different cellular responses, and are compatible with an ordered binding of Ca2+.
Journal ArticleDOI
Structural dynamics in the C-terminal domain of calmodulin at low calcium levels.
TL;DR: Characterization of chemical exchange as a function of Ca2+ concentration has enabled the extraction of unique information on the rapidly exchanging and weakly populated (<10 %) (Ca2+)1 state that is otherwise inaccessible to direct study due to strongly cooperativeCa2+ binding.
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The structure of the B subunit of calcineurin.
TL;DR: The complete primary structure of the B subunit of calcineurin (protein phosphatase 2B) has been determined by automated sequence analysis and shows 35% identity with the sequence of calmodulin and 29% with troponin C.
References
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Journal ArticleDOI
Carp Muscle Calcium-binding Protein II. STRUCTURE DETERMINATION AND GENERAL DESCRIPTION
TL;DR: The structure of crystalline carp muscle calcium-binding protein (parvalbumin) has been determined by x-ray diffraction techniques to nominal 1.85-A resolution and the electron density map is interpreted in terms of the 108 amino acid sequence described in Paper I in this series.
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The calcium and magnesium binding sites on cardiac troponin and their role in the regulation of myofibrillar adenosine triphosphatase.
TL;DR: Comparison by the Ca2+-binding properties of cardiac Tn and the cardiac myofibrillar ATPase activity as a function of [Ca2+] and at millimolar [Mg2+'] suggests that activation of the ATPase occurs over the same range of [ Ca2+.
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Macrocyclic polyethers and their complexes.
C. J. Pedersen,H. K. Frensdorff +1 more
TL;DR: Cyclic polyethers have been successfully employed, inter alia, in experiments with ionic compounds in organic solvents and in studies of ion transport in biological systems.
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Structural Similarities between the Ca2+-dependent Regulatory Proteins of 3':5'-Cyclic Nucleotide Phosphodiesterase and Actomyosin ATPase*
TL;DR: Results of studies of the Ca2+-dependent protein modulator of 3':5'-cyclic nucleotide phosphodiesterase isolated from bovine brain are presented which show its structural similarity to the Ca1+-binding subunit of muscle troponin.
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Vitamin D-dependent calcium-binding protein. Purification and some properties.
TL;DR: The purification procedure involved the use of ammonium sulfate precipitation, gel filtration on Sephadex G-100, and preparative disc electrophoresis, and an equation linearly relating binding protein concentration to binding activity indicated that the product was homogeneous with respect to size.