Journal ArticleDOI
Cognition In The Days Following Concussion: Comparison Of Symptomatic Vs Asymptomatic Athletes
TLDR
Injured athletes experiencing symptoms of concussion displayed impaired motor function and attention, although their learning and memory were preserved, in contrast with the improvement observed in asymptomatic and non-injured athletes.Abstract:
BACKGROUND\nConcussion is a common neurological injury occurring during contact sport. Current guidelines recommend that no athlete should return to play while symptomatic or displaying cognitive dysfunction. This study compared post-concussion cognitive function in recently concussed athletes who were symptomatic/asymptomatic at the time of assessment with that of non-injured (control) athletes.\n\n\nMETHODS\nProspective study of 615 male Australian Rules footballers. Before the season, all participants (while healthy) completed a battery of baseline computerised (CogSport) and paper and pencil cognitive tasks. Sixty one injured athletes (symptomatic = 25 and asymptomatic = 36) were reassessed within 11 days of being concussed; 84 controls were also reassessed. The serial cognitive function of the three groups was compared using analysis of variance.\n\n\nRESULTS\nThe performance of the symptomatic group declined at the post-concussion assessment on computerised tests of simple, choice, and complex reaction times compared with the asymptomatic and control groups. The magnitude of changes was large according to conventional statistical criteria. On paper and pencil tests, the symptomatic group displayed no change at reassessment, whereas large improvements were seen in the other two groups.\n\n\nCONCLUSION\nInjured athletes experiencing symptoms of concussion displayed impaired motor function and attention, although their learning and memory were preserved. These athletes displayed no change in performance on paper and pencil tests in contrast with the improvement observed in asymptomatic and non-injured athletes. Athletes experiencing symptoms of concussion should be withheld from training and competition until both symptoms and cognitive dysfunction have resolved.read more
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Journal ArticleDOI
Summary of evidence-based guideline update: Evaluation and management of concussion in sports Report of the Guideline Development Subcommittee of the American Academy of Neurology
Christopher C. Giza,Jeffrey S. Kutcher,Stephen Ashwal,Jeffrey T. Barth,Thomas S.D. Getchius,Gerard A. Gioia,Gary S. Gronseth,Kevin M. Guskiewicz,Steven Mandel,Geoffrey T. Manley,Douglas B. McKeag,David J. Thurman,Ross Zafonte +12 more
TL;DR: Data are insufficient to show that any intervention enhances recovery or diminishes long-term sequelae postconcussion, and practice recommendations are presented for preparation counseling, management of suspected concussion, and management of diagnosed concussion.
Journal ArticleDOI
Neuropsychology and clinical neuroscience of persistent post-concussive syndrome.
TL;DR: The focus of this review is on the current status of PPCS as a clinical entity from the perspective of recent advances in the biomechanical modeling of concussion in human and animal studies, particularly directed at a better understanding of the neuropathology associated with concussion.
Journal ArticleDOI
Temporal window of metabolic brain vulnerability to concussion: a pilot 1H-magnetic resonance spectroscopic study in concussed athletes--part III.
Roberto Vagnozzi,Stefano Signoretti,Barbara Tavazzi,Roberto Floris,A. Ludovici,Simone Marziali,Giuseppe Tarascio,Angela Maria Amorini,Valentina Di Pietro,Roberto Delfini,Giuseppe Lazzarino +10 more
TL;DR: Results of this pilot study carried out in a cohort of singly and doubly concussed athletes examined by H-MR spectroscopy for their NAA cerebral content at different time points after concussive events demonstrate that also in humans, concussion opens a temporal window of brain metabolic imbalance, the closure of which does not coincide with resolution of clinical symptoms.
Journal ArticleDOI
Natural History of Concussion in Sport Markers of Severity and Implications for Management
TL;DR: Delayed return to sport was associated with initially greater symptom load, prolonged headache, or subjective concentration deficits, and symptom assessment alone may be predictive of but may underestimate time to complete recovery, which may be better estimated with computerized cognitive testing.
Journal ArticleDOI
Temporal window of metabolic brain vulnerability to concussions: mitochondrial-related impairment--part I.
Roberto Vagnozzi,Barbara Tavazzi,Stefano Signoretti,Angela Maria Amorini,Antonio Belli,Marco Cimatti,Roberto Delfini,Valentina Di Pietro,Antonino Finocchiaro,Giuseppe Lazzarino +9 more
TL;DR: This study shows the existence of a temporal window of brain vulnerability in rats undergoing repeat mild traumatic brain injury (mTBI) delivered at increasing time intervals and shows the influence of TBI on acetyl-CoA, N- acetylaspartate acylase gene expression, and N-acetylas partylglutamate, thus providing novel data on cerebral biochemical changes occurring in head injury.