Giuseppe Lazzarino

TL;DR: Pressure overload triggers NOS3 uncoupling as a prominent source of myocardial ROS that contribute to dilatory remodeling and cardiac dysfunction, and reversal of this process by BH4 suggests a potential treatment to ameliorate the pathophysiology of chronic pressure-induced hypertrophy.

TL;DR: Results indicate that N-acetylaspartate determination by proton magnetic resonance spectroscopy represents a non-invasive tool to accurately measure changes in cerebral energy metabolism occurring in mild traumatic brain injury and may significantly improve the management of athletes suffering from concussion.

TL;DR: Results of this pilot study carried out in a cohort of singly and doubly concussed athletes examined by H-MR spectroscopy for their NAA cerebral content at different time points after concussive events demonstrate that also in humans, concussion opens a temporal window of brain metabolic imbalance, the closure of which does not coincide with resolution of clinical symptoms.

TL;DR: Information on absorption, distribution, metabolism and excretion of cyanidin-glycosides administered by main possible routes are largely insufficient, however, consisting findings allow looking at cyanidins as dietary compounds with a potential beneficial role for human health.

TL;DR: This study shows the existence of a temporal window of brain vulnerability in rats undergoing repeat mild traumatic brain injury (mTBI) delivered at increasing time intervals and shows the influence of TBI on acetyl-CoA, N- acetylaspartate acylase gene expression, and N-acetylas partylglutamate, thus providing novel data on cerebral biochemical changes occurring in head injury.