D
David Darby
Researcher at Florey Institute of Neuroscience and Mental Health
Publications - 164
Citations - 12713
David Darby is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: Cognition & Dementia. The author has an hindex of 54, co-authored 156 publications receiving 11805 citations. Previous affiliations of David Darby include Royal Melbourne Hospital & Austin Hospital.
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Journal ArticleDOI
Imaging beta-amyloid burden in aging and dementia.
Christopher C. Rowe,Steven Ng,Uwe Ackermann,Sylvia J. Gong,Kerryn E. Pike,Gregory Raymond Savage,Tiffany F. Cowie,Kerryn L Dickinson,Paul Maruff,David Darby,Clare Smith,Michael Woodward,John Merory,Henri Tochon-Danguy,Graeme O'Keefe,William E. Klunk,Chett A Mathis,Julie C. Price,Colin L. Masters,Colin L. Masters,Victor L. Villemagne,Victor L. Villemagne +21 more
TL;DR: Pittsburgh Compound B PET findings match histopathologic reports of β-amyloid (Aβ) distribution in aging and dementia, and suggest that Aβ may influence the development of dementia with Lewy bodies, and therefore strategies to reduce A β may benefit this condition.
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The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: Methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
Kathryn A. Ellis,Ashley I. Bush,David Darby,Daniela De Fazio,Jonathan K. Foster,Peter Hudson,Nicola T. Lautenschlager,Nat Lenzo,Ralph N. Martins,Paul Maruff,Colin L. Masters,Andrew Milner,Kerryn E. Pike,Christopher C. Rowe,Greg Savage,Cassandra Szoeke,Kevin Taddei,Victor L. Villemagne,Michael Woodward,David Ames +19 more
TL;DR: The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD.
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Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency.
Robert R. Edelman,Bettina Siewert,Bettina Siewert,David Darby,Venketasen Thangaraj,Anna C. Nobre,M.-Marsel Mesulam,Steven Warach +7 more
TL;DR: The EPISTAR technique is a rapid, noninvasive means for creating qualitative maps of cerebral blood flow and changes in the motor strip, primary visual cortex, and the motor area for eye movements were well localized to the cortical gray matter ribbon.
Journal ArticleDOI
Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI
P. A. Barber,David Darby,Patricia Desmond,Q Yang,Richard P. Gerraty,Damien Jolley,Geoffrey A. Donnan,BM Tress,Stephen M. Davis +8 more
TL;DR: Combined early PI and DWI can define different acute infarct patterns, which may allow the selection of rational therapeutic strategies based on the presence or absence of potentially salvageable ischemic tissue.
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Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study
Mark W Parsons,P. Alan Barber,Patricia Desmond,Tracey A. Baird,Tracey A. Baird,David Darby,Graham Byrnes,Brian M. Tress,Stephen M. Davis,Stephen M. Davis +9 more
TL;DR: Higher acute blood glucose in patients with perfusion‐diffusion mismatch was associated with greater acute‐subacute lactate production, which, in turn, was independently associated with reduced salvage of mismatch tissue, which support the need for randomized controlled trials of aggressive glycemic control in acute stroke.