Comparison between ultrafast and standard single-photon emission CT in patients with coronary artery disease: a pilot study.
Alessia Gimelli,Matteo Bottai,Assuero Giorgetti,Dario Genovesi,Annette Kusch,Andrea Ripoli,Paolo Marzullo +6 more
TLDR
This pilot study confirms that UF-SPECT provides high-quality fast myocardial perfusion imaging and suggests that it may allow a more-accurate evaluation of both extent and severity of myocardIAL ischemia in patients with coronary artery disease.Abstract:
Background— A novel technology has been developed for ultrafast (UF) single-photon emission CT (SPECT) myocardial perfusion imaging by using a pinhole collimation design and multiple cadmium zinc telluride crystal arrays. The purpose of this study was to compare myocardial perfusion imaging obtained by UF-SPECT with standard (S) SPECT in patients with known or suspected coronary artery disease.
Methods and Results— A total of 34 patients underwent single-day 99mTc-tetrofosmin stress/rest myocardial perfusion imaging. UF-SPECT was performed 10 minutes before S-SPECT. Images were qualitatively analyzed, and the summed stress score and summed rest score were calculated. The segmental tracer uptake value (percentage of maximum myocardial uptake) also was quantified for both UF- and S-SPECT. When only 29 of 34 patients with significant coronary lesions were analyzed, the summed stress score was 10.1±4.4 versus 6.4±2.9, respectively, for UF- and S-SPECT ( P =0.002). Qualitative and quantitative per-patient analysis showed similar results in detection of coronary artery disease for UF- and S-SPECT. In contrast, per-vessel analysis demonstrated higher regional sensitivity of UF- versus S-SPECT. UF-SPECT showed higher sensitivity in detecting multivessel disease ( P =0.003) versus S-SPECT.
Conclusions— This pilot study confirms that UF-SPECT provides high-quality fast myocardial perfusion imaging and suggests that it may allow a more-accurate evaluation of both extent and severity of myocardial ischemia in patients with coronary artery disease.read more
Citations
More filters
Journal ArticleDOI
High diagnostic accuracy of low-dose gated-SPECT with solid-state ultrafast detectors: preliminary clinical results
Alessia Gimelli,Matteo Bottai,Matteo Bottai,Dario Genovesi,Assuero Giorgetti,Fabio Di Martino,Paolo Marzullo +6 more
TL;DR: This pilot study demonstrated the feasibility of a low-dose single-day stress–rest fasting protocol performed using UF SPECT, with good sensitivity and specificity in detecting CAD at low patient exposure, opening new perspectives in the use of myocardial perfusion in ischaemic patients.
Journal ArticleDOI
Impact of a new ultrafast CZT SPECT camera for myocardial perfusion imaging: fewer equivocal results and lower radiation dose
Mohamed Mouden,Jorik R. Timmer,Jan Paul Ottervanger,Stoffer Reiffers,Ad H. J. Oostdijk,Siert Knollema,Pieter L. Jager +6 more
TL;DR: Stress myocardial perfusion images acquired on a CZT camera are more frequently interpreted as normal with identical clinical outcome after 1-year follow-up, which lowers the need for additional testing, results in lower mean radiation dose and shortens imaging time.
Journal ArticleDOI
Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM)
Denis Agostini,Pierre-Yves Marie,Simona Ben-Haim,François Rouzet,Bernard Songy,Alessandro Giordano,Alessia Gimelli,Fabien Hyafil,Roberto Sciagrà,Jan Bucerius,Hein J. Verberne,Riemer H. J. A. Slart,Oliver Lindner,Christopher Übleis,Marcus Hacker +14 more
TL;DR: In this article, the authors proposed a three-dimensional iterative reconstruction algorithm based on maximum likelihood expectation maximization (MLEM), which corrects for the loss in spatial resolution due to line response function of the collimator.
Journal ArticleDOI
Advances in nuclear cardiac instrumentation with a view towards reduced radiation exposure.
TL;DR: These technologies including new single photon emission computed tomography and positron emission tomography scanners, as well as novel reconstruction software with regard to their potential for the reduction of the patient radiation dose are discussed.
Journal ArticleDOI
Reduced stress dose with rapid acquisition CZT SPECT MPI in a non-obese clinical population: Comparison to coronary angiography
TL;DR: In this group of non-obese patients undergoing low stress dose imaging, high-efficiency CZT SPECT imaging demonstrated a high sensitivity, specificity, and accuracy for detecting obstructive epicardial CAD with a greatly reduced imaging time.
References
More filters
Journal ArticleDOI
Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
Manuel D. Cerqueira,Neil J. Weissman,Vasken Dilsizian,Alice K. Jacobs,Sanjiv Kaul,Warren K. Laskey,Dudley J. Pennell,John A. Rumberger,Thomas J. Ryan,Mario S. Verani +9 more
TL;DR: Attempts to standardize options for all cardiac imaging modalities should be based on the sound principles that have evolved from cardiac anatomy and clinical needs, and selection of standardized methods must bebased on the following criteria.
Journal ArticleDOI
Maximum Likelihood Reconstruction for Emission Tomography
L. A. Shepp,Y. Vardi +1 more
TL;DR: In this paper, the authors proposed a more accurate general mathematical model for ET where an unknown emission density generates, and is to be reconstructed from, the number of counts n*(d) in each of D detector units d. Within the model, they gave an algorithm for determining an estimate? of? which maximizes the probability p(n*|?) of observing the actual detector count data n* over all possible densities?.
Journal ArticleDOI
Accelerated image reconstruction using ordered subsets of projection data
H.M. Hudson,R.S. Larkin +1 more
TL;DR: Ordered subsets EM (OS-EM) provides a restoration imposing a natural positivity condition and with close links to the EM algorithm, applicable in both single photon (SPECT) and positron emission tomography (PET).
Journal ArticleDOI
ACC/AHA 2002 Guideline Update for Exercise Testing: Summary Article A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines)
Raymond J. Gibbons,Gary J. Balady,J. Timothy Bricker,Bernard R. Chaitman,Gerald F. Fletcher,Victor F. Froelicher,Daniel B. Mark,Ben D. McCallister,Aryan N. Mooss,Michael G. O’Reilly,William L. Winters,Elliott M. Antman,Joseph S. Alpert,David P. Faxon,Valentin Fuster,Gabriel Gregoratos,Loren F. Hiratzka,Alice K. Jacobs,Richard O. Russell,Sidney C. Smith +19 more
TL;DR: The American College of Cardiology (ACC)/AHA Task Force on Practice Guidelines regularly reviews existing guidelines to determine when an update or full revision is needed.
Journal Article
EM reconstruction algorithms for emission and transmission tomography.
Kenneth Lange,Richard E. Carson +1 more
TL;DR: The general principles behind all EM algorithms are discussed and in detail the specific algorithms for emission and transmission tomography are derived and the specification of necessary physical features such as source and detector geometries are discussed.