Journal ArticleDOI
Comparison of minimally invasive surgery with laparotomic approach in the treatment of high risk endometrial cancer: A systematic review
G. Scaletta,Giorgia Dinoi,VA Capozzi,Stefano Cianci,Silvia Pelligra,Raffaella Ergasti,Anna Fagotti,Giovanni Scambia,Francesco Fanfani +8 more
TLDR
MIS appears to be safe in the management of high-risk EC patients, showing better perioperative and postoperative outcomes and comparable oncological outcomes than open surgery.Abstract:
Objective To analyze all published studies comparing minimally invasive surgery (MIS) with laparotomic one in the surgical treatment of high-risk endometrial cancer (EC) in term of operative, peri-operative and oncological outcomes. Data sources We conducted a systematic literature search in PubMed between January 1995–March 2019. Methods of study selection Titles and abstracts were analyzed by two reviewers. A set of explicit criteria was used for selection of literature: 1) randomized controlled trials (RCT), prospective or retrospective cohort studies, given the rarity of this tumor and the concomitant lack of data in the form of large trials, all reviewed original report publications with an appropriate number of subjects were considered and included; 2) participants of interest being patients who have suffered from high risk EC 3) the outcome measures including overall survival (OS), disease-free survival (DFS) and recurrence, (4) English language, (5) abstract available. Results Thirty relevant articles were selected for full reading. For final analysis 20 studies were selected. Then, as second step, the full articles were evaluated to determine whether full inclusion criteria were met. In total, 9 papers were identified and included. Conclusion MIS appears to be safe in the management of high-risk EC patients, showing better perioperative and postoperative outcomes and comparable oncological outcomes than open surgery. Prospective randomized trial would be needed to confirm this data.read more
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Novelties of ultrasound imaging for endometrial cancer preoperative workup.
Vito Andrea Capozzi,Andrea Rosati,Valerio Rumolo,Federico Ferrari,Giuseppe Gullo,Erbil Karaman,Onur Karaaslan,Latif Hacioğlu +7 more
TL;DR: TVU sensitivity and specificity in myometrial infiltration and cervical invasion is comparable to MRI but has lower costs, greater patient tolerability, and does not require contrast agents.
Journal ArticleDOI
Fertility-sparing management for endometrial cancer: review of the literature.
Simone Garzon,Stefano Uccella,Pier Carlo Zorzato,Mariachiara Bosco,Massimo Franchi,Vladimir Student,Andrea Mariani +6 more
TL;DR: Fertility preservation appears feasible in young patients with grade 1 EC limited to the endometrium or atypical endometrial hyperplasia, and the addition of Metformin and hysteroscopic resection seems to provide some improvements.
Journal ArticleDOI
Quality of life and sexual functioning of patient affected by endometrial cancer.
Stefano Cianci,Andrea Rosati,Vito Andrea Capozzi,Mattia Tarascio,Stefano Uccella,Marco Palumbo,Salvatore Caruso +6 more
TL;DR: Considering the widespread diffusion of female sexual dysfunction among EC patients and the relatively good prognosis, especially in early stage disease, it undoubtedly looms the need for proactive countermeasures to maximize the sexual well-being and QoL of these patients.
Journal ArticleDOI
Surgical complications occurring during minimally invasive sentinel lymph node detection in endometrial cancer patients. A systematic review of the literature and metanalysis
Vito Andrea Capozzi,Gaetano Riemma,Andrea Rosati,Virginia Vargiu,Roberta Granese,Alfredo Ercoli,Stefano Cianci +6 more
TL;DR: In this article, the authors performed a meta-analysis of laparoscopic versus robotic lymphadenectomy (L-LND) for endometrial cancer and reported a lower surgical complications rate in patients undergoing L-SLN technique compared to L-RND.
Journal ArticleDOI
Sentinel lymph node for endometrial cancer treatment: review of the literature.
Pier Carlo Zorzato,Mariachiara Bosco,Massimo Franchi,Andrea Mariani,Stefano Cianci,Simone Garzon,Stefano Uccella +6 more
TL;DR: SLN mapping in apparently uterine confined disease has been demonstrated to be a feasible and accurate technique for nodal evaluation and high-quality evidence support this, while high- quality evidence is not available on long-term oncologic safety of this technique compared to the standard LND.
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Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer
Pedro T. Ramirez,Michael Frumovitz,Rene Pareja,Aldo Lopez,Marcelo Vieira,Reitan Ribeiro,Alessandro Buda,Xiaojian Yan,Yao Shuzhong,Naven Chetty,David Isla,Mariano Tamura,Tao Zhu,Kristy P. Robledo,Val Gebski,Rebecca Asher,Vanessa Behan,James L. Nicklin,Robert L. Coleman,Andreas Obermair +19 more
TL;DR: In this trial, minimally invasive radical hysterectomy was associated with lower rates of disease‐free survival and overall survival than open abdominal radical hysteresis among women with early‐stage cervical cancer.
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Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study LAP2
Joan L. Walker,Marion Piedmonte,Nick M. Spirtos,Scott M. Eisenkop,John B. Schlaerth,Robert S. Mannel,Gregory Spiegel,Richard Barakat,Michael L. Pearl,Sudarshan K. Sharma +9 more
TL;DR: Laroscopic surgical staging for uterine cancer is feasible and safe in terms of short-term outcomes and results in fewer complications and shorter hospital stay.
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ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up
Nicoletta Colombo,Carien L. Creutzberg,Frédéric Amant,Tjalling Bosse,Antonio González-Martín,Jonathan A. Ledermann,Christian Marth,Remi A. Nout,Denis Querleu,Mansoor Raza Mirza,Cristiana Sessa +10 more
TL;DR: The first joint European Society for Medical Oncology (ESMO), European SocieTy for Radiotherapy & Oncologies (ESTRO), and European Society of Gynaecological Oncologists (ESGO) consensus conference on endometrial cancer was held on 11-13 December 2014 in Milan, Italy, and comprised a multidisciplinary panel of 40 leading experts in the management of endometrium cancer as discussed by the authors.