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Complications of hypertension and the role of angiotensin receptor blockers in hypertension trials.
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TLDR
The results may indicate that ARBs have a superior effect compared with placebo or other antihypertensive drugs in order to prevent left ventricular hypertrophy, atrial fibrillation, stroke, renal disease and diabetes mellitus, while there appears to be no blood pressure-independent superior effect of ARBs regarding prevention of myocardial infarction or heart failure.Abstract:
Hypertension is a high-prevalence disease that may affect several organs. In recent years, data have accumulated indicating that angiotensin II receptor blockers (ARBs) may have a supplementary effect beyond lowering blood pressure. The aim of this review is to evaluate the impact of ARBs on the most important complications of hypertension – heart, cerebrovascular and renal diseases, and metabolic complications – based on the findings from large clinical hypertension trials. The results may indicate that ARBs have a superior effect compared with placebo or other antihypertensive drugs in order to prevent left ventricular hypertrophy, atrial fibrillation, stroke, renal disease and diabetes mellitus, while there appears to be no blood pressure-independent superior effect of ARBs regarding prevention of myocardial infarction or heart failure.read more
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Modifications by Olmesartan medoxomil treatment of the platelet protein profile of moderate hypertensive patients
Daniel Sacristán,Maria Jose Marques,José J. Zamorano-León,M. Luque,Juan Jorge González Armengol,Juan González Del Castillo,Javier Espino Martín,Eva Delpón,Priscila Ramos-Mozo,Teresa Pérez de Prada,Juan Tamargo,Alberto Barrientos,Carlos Macaya,Antonio J. López-Farré +13 more
TL;DR: Olmesartan medoxomil reduced SBP, total and LDL‐cholesterol plasma levels and urinary protein excretion and induced changes in the expression of platelet proteins which may be related to some action of the drug at the megakaryocyte level.
Journal ArticleDOI
Optimization of hypertension management: the role of angiotensin receptor blocker-calcium channel blocker combinations.
TL;DR: The combination of angiotensin receptor antagonists with calcium channel blockers has been shown to provide well-tolerated antihypertensive efficacy, which is greater than that of monotherapy with either agent, and lacks adverse metabolic effects.
Journal ArticleDOI
Management of hypertension in the outpatient setting.
TL;DR: The treatment of hypertension on an outpatient basis should be approached in a systematic manner and ongoing attention should be directed to long-term adherence to therapy.
Journal ArticleDOI
Downregulation of Brain Gα12 Attenuates Angiotensin II-Dependent Hypertension
TL;DR: Findings suggest that central Gα12 protein signaling pathways play an important role in the development of chronic AngII-dependent hypertension in rats.
References
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K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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Role of Insulin Resistance in Human Disease
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Journal ArticleDOI
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TL;DR: Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg.
Journal ArticleDOI
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Barry M. Brenner,Mark E. Cooper,Dick de Zeeuw,William F. Keane,William E. Mitch,Hans-Henrik Parving,Giuseppe Remuzzi,Steven M. Snapinn,Zhonxin Zhang,Shahnaz Shahinfar +9 more
TL;DR: Losartan conferred significant renal benefits in patients with type 2 diabetes and nephropathy, and it was generally well tolerated.
Journal ArticleDOI
Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes
Edmond J Lewis,Lawrence G. Hunsicker,William R. Clarke,Tomas Berl,Marc A. Pohl,Julia B. Lewis,Eberhard Ritz,Robert C. Atkins,Richard D. Rohde,Itamar Raz +9 more
TL;DR: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes, independent of the reduction in blood pressure it causes.