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Open AccessJournal ArticleDOI

Comprehensive Decision Tree Models in Bioinformatics

Gregor Stiglic, +3 more
- 30 Mar 2012 - 
- Vol. 7, Iss: 3, pp 1-13
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TLDR
By building simple models constrained by predefined visual boundaries, one not only achieves good comprehensibility, but also very good classification performance that does not differ from usually more complex models built using default settings of the classical decision tree algorithm.
Abstract
Purpose Classification is an important and widely used machine learning technique in bioinformatics. Researchers and other end-users of machine learning software often prefer to work with comprehensible models where knowledge extraction and explanation of reasoning behind the classification model are possible.

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Unbox the black-box for the medical explainable AI via multi-modal and multi-centre data fusion: A mini-review, two showcases and beyond

TL;DR: This study surveyed the current progress of XAI and in particular its advances in healthcare applications, and introduced the solutions for XAI leveraging multi-modal and multi-centre data fusion, and subsequently validated in two showcases following real clinical scenarios.
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Interpretability of machine learning‐based prediction models in healthcare

TL;DR: In this article, the authors give an overview of interpretability approaches and provide examples of practical interpretability of machine learning in different areas of healthcare, including prediction of health-related outcomes, optimizing treatments or improving the efficiency of screening for specific conditions.
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Unbox the black-box for the medical explainable AI via multi-modal and multi-centre data fusion: A mini-review, two showcases and beyond

TL;DR: Explainable Artificial Intelligence (XAI) is an emerging research topic of machine learning aimed at unboxing how AI systems' black-box choices are made as mentioned in this paper , which is particularly true of the most popular deep neural network approaches currently in use.
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A review of machine learning methods to predict the solubility of overexpressed recombinant proteins in Escherichia coli.

TL;DR: This paper presents an extensive review of the existing models to predict protein solubility in Escherichia coli recombinant protein overexpression system and concludes that some of the models present acceptable prediction performances and convenient user interfaces can be considered as valuable tools to predict recombinant Protein Solubility results before performing real laboratory experiments, thus saving labour, time and cost.
References
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Journal ArticleDOI

Random Forests

TL;DR: Internal estimates monitor error, strength, and correlation and these are used to show the response to increasing the number of features used in the forest, and are also applicable to regression.
Book

The Nature of Statistical Learning Theory

TL;DR: Setting of the learning problem consistency of learning processes bounds on the rate of convergence ofLearning processes controlling the generalization ability of learning process constructing learning algorithms what is important in learning theory?
Journal ArticleDOI

The WEKA data mining software: an update

TL;DR: This paper provides an introduction to the WEKA workbench, reviews the history of the project, and, in light of the recent 3.6 stable release, briefly discusses what has been added since the last stable version (Weka 3.4) released in 2003.