Computer Simulation of Granulopoiesis: Normal and Impaired Granulopoiesis
Eric A. King-Smith,Alec Morley +1 more
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This model re- cause granulopoiesis is a feedback-conproduced the low-amplitude neutrophil trolled system and suggest that the main oscillation reported in normal individuals assumptions of the model have physical and, when mild and severe marrow fail- reality.About:
This article is published in Blood.The article was published on 1970-08-01 and is currently open access. It has received 114 citations till now. The article focuses on the topics: Negative feedback.read more
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Unified hypothesis for the origin of aplastic anemia and periodic hematopoiesis
TL;DR: It is concluded that the dynamics of PH probably originate in the hematopoietic pluripotential stem cell (PPSC) population and the simplest hypothesis for the origin of aplastic anemia (AA) and PH is that they are both due to the irreversible loss of proliferative stem cells.
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Pathological conditions resulting from instabilities in physiological control systems
Leon Glass,Michael C. Mackey +1 more
TL;DR: The changes in qualitative dynamics associated with the onset of the disease are identified with bifurcations in the dynamics of mathematical models of the physiological control systems.
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Chronobiology in hematology and immunology
TL;DR: Differences in response, and susceptibility of cells and tissues at different stages of their circadian and circaseptan rhythms and presumably of cyclic variations in other frequencies are expected to lead to the development of a chronopharmacology of the hematopoietic and immune system.
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Cyclical Neutropenia and Other Periodic Hematological Disorders: A Review of Mechanisms and Mathematical Models
Caroline Haurie,Caroline Haurie,David C. Dale,David C. Dale,Michael C. Mackey,Michael C. Mackey +5 more
TL;DR: It is argued that the available evidence indicates that the locus of the defect in most of these dynamic diseases is at the stem cell level (auto-immune hemolytic anemia and cyclical thrombocytopenia seem to be the exceptions).
References
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The Effect of Erythropoietic Stimulation on the Hemopoietic Colony-forming Cells of Mice
TL;DR: It is suggested that the late decrease in colony-forming cells in the spleen is a response to a depleted pool of cells sensitive to erythropoietin and that colony-formed cells are differentiated to produce more of these cells.