Journal ArticleDOI
Conformation of histamine derivatives. 3. A relationship between conformation and pharmacological activity.
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This article is published in Journal of Medicinal Chemistry.The article was published on 1973-06-01. It has received 70 citations till now. The article focuses on the topics: Histamine & Biological activity.read more
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Histamine food poisoning: toxicology and clinical aspects.
TL;DR: The efficacy of antihistamine therapy, the allergic-like symptomology, and the finding of high levels of histamine in the implicated food suggest strongly that histamine is the causative agent, however, histamines ingested with spoiled fish appears to be much more toxic than histamine ingested in an aqueous solution.
Journal ArticleDOI
Binding of flexible ligands to macromolecules
TL;DR: The formation of such a ligand–macromolecule complex must involve a process of conformational selection, which will influence the binding constant and the kinetics of complex formation.
Journal ArticleDOI
Sulphur-methylene isosterism in the developent of metiamide, a new histamine H 2 -receptor antagonist
TL;DR: Compared the relative species populations of the respective rings and modified the burimamide structure so as to increase the equilibrium concentration of imidazole species considered most likely to be active, to explore the therapeutic potential of this new type of drug action.
Journal ArticleDOI
Classification and biological distribution of histamine receptor sub-types
Naresh Chand,Peter Eyre +1 more
TL;DR: It can be concluded that both H1- and H2-receptors are widely distributed throughout the animal body in the gastro-intestinal, reproductive, respiratory and cardiovascular systems, nervous system and on mast cells and blood leucocytes.