Copper‐Mediated and Catalyzed C‐H Bond Amination via Chelation‐Assistance : Scope, Mechanism and Synthetic Applications

TLDR: In this article , the research progress of copper-catalyzed C-H amination in recent years is summarized and reaction mechanisms are also briefly described in representative aminations to provide insights for the development prospects of highly practical and more environmentally benign processes.

Abstract: Nitrogen-containing compounds are ubiquitously found in the fields of organic chemistry, pharmaceuticals, agrochemicals, medicinal chemistry and functional materials. The C—H bond amination reaction is one of the most straightforward protocols in the C—N bond formation, showing "step" and "atomic" economy. As a catalyst for C—H amination reaction, copper exhibits its unique catalytic properties due to easily accessible oxidation states. The research progress of copper-catalyzed C—H amination in recent years is summarized. At the same time, reaction mechanisms are also briefly described in representative aminations to provide insights for the development prospects of highly practical and more environmentally benign processes.