Open Access
Correlation between TGF-β1 expression and proteomic profiling induced by severe acute respiratory syndrome coronavirus papain-like protease
Shih-Wein) 李詩雯(Li,楊翠青(Tsuey-Ching Yang),萬磊(Lei Wan),林應如(Ying-Ju Lin),蔡輔仁(Fuu-Jen Tsai),賴建成(Chien-Chen Lai),林振文(Lin Cheng Wen) +6 more
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The article was published on 2012-11-01 and is currently open access. It has received 9 citations till now. The article focuses on the topics: Proteomic Profiling.read more
Citations
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SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway
Shih Wein Li,Ching Ying Wang,Yu Jen Jou,Tsuey Ching Yang,Su Hua Huang,Lei Wan,Ying Ju Lin,Cheng Wen Lin,Cheng Wen Lin +8 more
TL;DR: The results revealed that SARS-CoV PLpro significantly triggered Egr-1 dependent activation of TGF-β1 promoter via ROS/p38 MAPK/STAT3 pathway, correlating with up-regulation of pro-fibrotic responses in vitro and in vivo.
Journal ArticleDOI
COVID-19: viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection.
Francesco Messina,Emanuela Giombini,Chiara Agrati,Francesco Vairo,Tommaso Ascoli Bartoli,Samir Al Moghazi,Mauro Piacentini,Franco Locatelli,Gary P. Kobinger,Markus Maeurer,Alimuddin Zumla,Alimuddin Zumla,Maria Rosaria Capobianchi,Francesco Nicola Lauria,Giuseppe Ippolito +14 more
TL;DR: A network-based model is developed with the aim to define molecular aspects of pathogenic phenotypes in HCoV infections and may facilitate the process of structure-guided pharmaceutical and diagnostic research with the prospect to identify potential new biological targets.
Journal ArticleDOI
Cytoskeleton-a crucial key in host cell for coronavirus infection.
TL;DR: New insights are provided for fundamental virology and the control of CoV infection as dynamic interactions between actin filaments, microtubules, intermediate Filaments, and CoVs are discussed.
Journal ArticleDOI
Viruses as key modulators of the TGF‐β pathway; a double‐edged sword involved in cancer
TL;DR: Given the axial role of this pathway in tumorigenesis, it can be regarded as an attractive target for cancer therapy and further investigations on this subject may represent molecular targets among either TGF‐β signaling molecules or viral factors for the treatment and management of viral infection consequences such as cancer.
Journal ArticleDOI
Human coronaviruses: Clinical features and phylogenetic analysis.
Shih-Wen Li,Cheng Wen Lin +1 more
TL;DR: Differences in the genomes of certain HCoV strains, the pathogenesis of said strains, and recent developments in the establishment of therapeutic agents that might aid in the treatment of patients with such infections are focused on.
References
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Journal ArticleDOI
SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway
Shih Wein Li,Ching Ying Wang,Yu Jen Jou,Tsuey Ching Yang,Su Hua Huang,Lei Wan,Ying Ju Lin,Cheng Wen Lin,Cheng Wen Lin +8 more
TL;DR: The results revealed that SARS-CoV PLpro significantly triggered Egr-1 dependent activation of TGF-β1 promoter via ROS/p38 MAPK/STAT3 pathway, correlating with up-regulation of pro-fibrotic responses in vitro and in vivo.
Journal ArticleDOI
COVID-19: viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection.
Francesco Messina,Emanuela Giombini,Chiara Agrati,Francesco Vairo,Tommaso Ascoli Bartoli,Samir Al Moghazi,Mauro Piacentini,Franco Locatelli,Gary P. Kobinger,Markus Maeurer,Alimuddin Zumla,Alimuddin Zumla,Maria Rosaria Capobianchi,Francesco Nicola Lauria,Giuseppe Ippolito +14 more
TL;DR: A network-based model is developed with the aim to define molecular aspects of pathogenic phenotypes in HCoV infections and may facilitate the process of structure-guided pharmaceutical and diagnostic research with the prospect to identify potential new biological targets.
Journal ArticleDOI
Cytoskeleton-a crucial key in host cell for coronavirus infection.
TL;DR: New insights are provided for fundamental virology and the control of CoV infection as dynamic interactions between actin filaments, microtubules, intermediate Filaments, and CoVs are discussed.
Journal ArticleDOI
Viruses as key modulators of the TGF‐β pathway; a double‐edged sword involved in cancer
TL;DR: Given the axial role of this pathway in tumorigenesis, it can be regarded as an attractive target for cancer therapy and further investigations on this subject may represent molecular targets among either TGF‐β signaling molecules or viral factors for the treatment and management of viral infection consequences such as cancer.
Journal ArticleDOI
Human coronaviruses: Clinical features and phylogenetic analysis.
Shih-Wen Li,Cheng Wen Lin +1 more
TL;DR: Differences in the genomes of certain HCoV strains, the pathogenesis of said strains, and recent developments in the establishment of therapeutic agents that might aid in the treatment of patients with such infections are focused on.