Journal ArticleDOI
Crystal structures of functional building blocks derived from bis(benzo[b]thiophen-2-yl)methane.
TLDR
In (I), the edge-to-face interactions seen between two napthyl residues in (VII) are substituted by S...π contacts between the benzo[b]thiophen-2-yl units in (I).Abstract:
The syntheses of three bis(benzo[b]thiophen-2-yl)methane derivatives, namely bis(benzo[b]thiophen-2-yl)methanone, C17H10OS2, (I), 1,1-bis(benzo[b]thiophen-2-yl)-3-(trimethylsilyl)prop-2-yn-1-ol, C22H20OS2Si, (II), and 1,1-bis(benzo[b]thiophen-2-yl)prop-2-yn-1-ol, C19H12OS2, (III), are described and their crystal structures discussed comparatively. The conformation of ketone (I) and the respective analogues are rather similar for most of the compounds compared. This is true for the interplanar angles, the Caryl-Cbridge-Caryl angles and the dihedral angles. The best resemblance is found for a bioisotere of (I), viz. 2,2'-dinaphthyl ketone, (VII). By way of interest, the crystal packings also reveal similarities between (I) and (VII). In (I), the edge-to-face interactions seen between two napthyl residues in (VII) are substituted by S...π contacts between the benzo[b]thiophen-2-yl units in (I). In the structures of the bis(benzo[b]thiophen-2-yl)methanols, i.e. (II) and (III), the interplanar angles are also quite similar compared with analogues and related active pharmaceutical ingredients (APIs) containing the dithiophen-2-ylmethane scaffold, though the dihedral angles show a larger variability and produce unsymmetrical molecules.read more
Citations
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Journal ArticleDOI
Comprehensive Supramolecular Chemistry. 11 Volumes. Editor-in-chief Jean-Marie Lehn (Université Louis Pasteur, France). Edited by Jerry L. Atwood (University of Missouri), J. Eric Davies (University of Lancaster, U.K.), David D. Macnicol (University of Glasgow), and Fritz Vogtle (Friedrich-Willhelms-Universität, Germany). Pergamon: Oxford. 1996. 6672 pp. $4320. ISBN 0-08-040610-6 (set).
Journal ArticleDOI
Structural study involving 9-(pyrid-2-yl)indolizine-1-one and related derivatives of dipyridyl methanol
TL;DR: In this article, the synthesis of 9-(pyrid-2-yl)indolizine-1-one from dipyridylpropargyl alcohol together with its molecular structure is reported.
References
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