Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review
Cristina Blebea,L. Ujvary,Violeta Necula,Maximilian George Dindelegan,Maria Perde-Schrepler,Mirela Cristina Stamate,Marcel Cosgarea,Alma Maniu +7 more
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TLDR
The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals, and the assessment of new pharmacological options, novel bioactive molecules, nanoparticles, stem cells, and gene therapy.Abstract:
Hearing loss is the most common neurosensory disorder, and with the constant increase in etiological factors, combined with early detection protocols, numbers will continue to rise. Cochlear implantation has become the gold standard for patients with severe hearing loss, and interest has shifted from implantation principles to the preservation of residual hearing following the procedure itself. As the audiological criteria for cochlear implant eligibility have expanded to include patients with good residual hearing, more attention is focused on complementary development of otoprotective agents, electrode design, and surgical approaches. The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals. Subsequently, the assessment of new pharmacological options, novel bioactive molecules (neurotrophins, growth factors, etc.), nanoparticles, stem cells, and gene therapy are discussed.read more
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The Effect of Pluronic-Coated Gold Nanoparticles in Hearing Preservation Following Cochlear Implantation-Pilot Study
Cristina Blebea,Violeta Necula,Monica Potara,Maximilian George Dindelegan,L. Ujvary,Emil Botan,Alma Maniu,Marcel Cosgarea +7 more
TL;DR: The local application of Pluronic-coated gold nanoparticles containing Dex-Plu-AuNPs following cochlear implantation may better protect the residual hearing than dexamethasone alone, but a larger sample size is needed to reach a possible statistical significance.
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Self-assessment of cochlear health by cochlear implant recipients
TL;DR: In this paper , the authors evaluated the feasibility of using a cochlear implant (CI) telemetry to assess CH and examined patterns of electrode impedances, electrically-evoked compound action potentials (eCAPs) and electrocochleography (ECochGs), over time, in a group of adult CI recipients.
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Relevant Anatomical Details in Rats Regarding Otologic Research
Cristina Blebea,Maximilian George Dindelegan,L. Ujvary,Sergiu Susman,Alma Maniu,Marcel Cosgarea +5 more
TL;DR: In this paper , a detailed anatomical description of the rat's ear anatomy was provided, which will prove insightful to different experimental otologic surgical procedures regardless of scope, and the most relevant images from all three rats were selected for representation.
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Development of otic organoids and their current status
TL;DR: Otic organoids have been used for disease modeling and are expected to be more widely applied in various areas of research on the inner ear as discussed by the authors , including hearing restoration and prevention; thus, it is essential to produce otic organoid that contain cochlear hair cells.
References
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Journal ArticleDOI
A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.
TL;DR: Results indicate that the MAPK–JNK signal pathway is involved in both ototoxicity and acoustic trauma-induced hair cell loss and permanent hearing loss.
Journal Article
Intracochlear placement of cochlear implant electrodes in soft surgery technique
TL;DR: Observations suggest that the experienced surgeon can effect preservation of residual hearing for patients who cannot derive significant benefits from conventional acoustic amplifiers.
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Cochlear implantation via the round window membrane minimizes trauma to cochlear structures: A histologically controlled insertion study
Oliver F. Adunka,Marc H. Unkelbach,Martin G. Mack,Markus Hambek,Wolfgang Gstoettner,Jan Kiefer +5 more
TL;DR: Insertions through the round window membrane were shown to be atraumatic, even in basal cochlear regions, and might be very effective for combined electric and acoustic stimulation of the auditory system.
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NAC for noise: From the bench top to the clinic
Richard D. Kopke,Ronald L. Jackson,John K.M. Coleman,Jianzhong Liu,Jianzhong Liu,Eric C. Bielefeld,Ben J. Balough +6 more
TL;DR: This article reviews one such compound, N-acetylcysteine (NAC), in terms of its efficacy in reducing hearing loss in a variety of animal models of acute acoustic trauma and hypothesizes what its therapeutic mechanisms of action might be based on the known actions of NAC.
Hereditary Hearing Loss and Deafness Overview
TL;DR: This overview focuses on the clinical features and molecular genetics of common syndromic and nonsyndromic types of hereditary hearing loss.