Journal ArticleDOI
Current status of platinum-based antitumor drugs.
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This article is published in Chemical Reviews.The article was published on 1999-08-17. It has received 1671 citations till now.read more
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Cellular processing of platinum anticancer drugs.
Dong Wang,Stephen J. Lippard +1 more
TL;DR: This review focuses on recently discovered cellular pathways that are activated in response to cisplatin, including those involved in regulating drug uptake, the signalling of DNA damage, cell-cycle checkpoints and arrest, DNA repair and cell death.
Journal ArticleDOI
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo‐ and Stereoselective Hydrogenation of Ketones
Ryoji Noyori,Takeshi Ohkuma +1 more
TL;DR: The newly devised [RuCl(2)(phosphane)(2)(1,2-diamine)] complexes are excellent precatalysts for homogeneous hydrogenation of simple ketones which lack any functionality capable of interacting with the metal center.
Journal ArticleDOI
Direct cellular responses to platinum-induced DNA damage
Yongwon Jung,Stephen J. Lippard +1 more
Journal ArticleDOI
Cisplatin: The first metal based anticancer drug.
TL;DR: This article highlights a systematic description on cisplatin which includes a brief history, synthesis, action mechanism, resistance, uses, side effects and modulation of side effects.
Journal ArticleDOI
Biological properties of “naked” metal nanoparticles
TL;DR: The novel biological properties and applications of three most widely used metal nanoparticles, namely, the nanoparticles of gold, silver and platinum are discussed.
References
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Journal ArticleDOI
Platinum Compounds: a New Class of Potent Antitumour Agents
TL;DR: The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice and reversibly inhibit cell division in Gram-negative rods1–4.
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Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
TL;DR: In E. coli, the presence of certain group VIIIb transition metal compounds in concentrations of about 1–10 parts per million of the metal in the culture medium causes an inhibition of the cell division process, which implies that the growth process is not markedly affected.
Journal ArticleDOI
Structure, Recognition, and Processing of Cisplatin-DNA Adducts.
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Carboplatin dosage: prospective evaluation of a simple formula based on renal function.
Ah Calvert,David Richard Newell,L A Gumbrell,S O'Reilly,M Burnell,F. E. Boxall,Zahid H Siddik,Ian Judson,Martin Gore,E Wiltshaw +9 more
TL;DR: The formula provides a simple and consistent method of determining carboplatin dose in adults and will not be influenced by previous or concurrent myelosuppressive therapy or supportive measures, and is applicable to combination and high-dose studies as well as conventional single-agent therapy, although the target AUC will need to be redefined for combination chemotherapy.
Journal ArticleDOI
Clinical development of platinum complexes in cancer therapy: an historical perspective and an update
David Lebwohl,R Canetta +1 more
TL;DR: The clinical development of platinum coordination complexes, with emphasis on those compounds still under active development, is reviewed, and new compounds clearly more active than or non-cross-resistant with cisplatin have not yet been identified.