Journal ArticleDOI
Cyclic 3', 5'-AMP and theophylline inhibit epidermal mitosis in G2-phase.
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This article is published in Naturwissenschaften.The article was published on 1972-01-01. It has received 39 citations till now. The article focuses on the topics: Theophylline.read more
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Cyclic AMP in relation to proliferation of the Epidermal cell: a new view
TL;DR: Four agents known to increase the level of cellular cAMP by different means increase the growth of colonies of cultured human epidermal cells and of keratinocytes derived from other stratified squamous epithelia, suggesting that cell proliferation in the intact epidermis is regulated through agents affecting cAMP.
Journal ArticleDOI
Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured human keratinocytes
TL;DR: It is shown that VIP, in the presence of lethally treated 3T3 fibroblast feeder cells and epidermal growth factor (EGF), stimulated proliferation of keratinocytes in a dose-dependent manner, whereas SP, CGRP, and SOM were ineffective.
Journal ArticleDOI
Cyclic AMP, cyclic GMP, and glucocorticoids as potential metabolic regulators of epidermal proliferation and differentiation.
TL;DR: It is believed that cyclic nucleotides are of central importance in the pathogenesis of the epidermal component of psoriasis.
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Phosphorylation of Epidermal Keratins
TL;DR: It is found that a 63,000 molecular weight phosphoprotein is present in uninvolved skin but absent in the psoriatic plaques.
References
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Journal ArticleDOI
The study of mammalian epidermal mitosis in vitro: A critical analysis of technique
W. S. Bullough,Edna B. Laurence +1 more
Journal ArticleDOI
The adenyl cyclase of skin. I. Measurement and properties.
P.D. Mier,E. Urselmann +1 more
TL;DR: A method is described for the measurement of cutaneous adenyl cyclase, which appears to be unusual in that no stimulation of its activity by adrenalin could be demonstrated.