Journal ArticleDOI
Cyclocondensation reaction of 4-aryl-4-methoxy-1,1,1-trifluoro-3-buten-2-ones with urea Synthesis of novel 6-aryl(5-methyl)-4-trifluoromethyl-2(1H)-pyrimidinones
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TLDR
In this article, the synthesis of a series of 6-aryl(5-methyl)-4-trifluoromethyl-2(1H)-pyrimidinones from the reaction of 4-aryl-4-methoxy-1, 1,1,1-, trifluoro-3-buten-2-ones with urea in the presence of hydrochloric acid was reported.About:
This article is published in Journal of Fluorine Chemistry.The article was published on 2003-03-01. It has received 36 citations till now. The article focuses on the topics: Aryl & Trifluoromethyl.read more
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Journal ArticleDOI
Recent advances in the chemistry of α,β-unsaturated trifluoromethylketones
Journal ArticleDOI
Regiospecific Synthesis of 4-Alkoxy and 4-Amino Substituted 2-Trifluoromethyl Pyrroles
Nilo Zanatta,Juliana M. F. M. Schneider,Paulo H. Schneider,Ana D. Wouters,Helio G. Bonacorso,Marcos A. P. Martins,Ludger A. Wessjohann +6 more
TL;DR: A simple and regiospecific synthesis of 4-alkoxy(amino)-2-trifluoromethyl pyrroles from 5-azido-4-alkyl-1-1,1- trifluoro-pent-3-en-2-ones by an aza-Wittig cyclization of aminophosphoranes is described.
Journal ArticleDOI
Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and β-enamino trihalomethyl ketones in water
Marcos A. P. Martins,Claudio M. P. Pereira,Wilson Cunico,Sidnei Moura,Fernanda A. Rosa,Rodrigo L. Peres,Pablo Machado,Nilo Zanatta,Helio G. Bonacorso +8 more
TL;DR: A convenient method for the preparation of 5-hydroxy-5-trihalo-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones from the reaction of 1,1,1-triHalo- 4-alkoxy-3-alken-2-ones with hydroxylamine and anilines using water as solvent and under ultrasound irradiation is reported.
Journal ArticleDOI
Indium(III) bromide catalyzed one-pot synthesis of trichloromethylated tetrahydropyrimidinones
Marcos A. P. Martins,Marcos V. M. Teixeira,Wilson Cunico,Elisandra Scapin,Rodrigo Mayer,Claudio M. P. Pereira,Nilo Zanatta,Helio G. Bonacorso,Clovis Peppe,Yao-Feng Yuan +9 more
TL;DR: One-pot condensation of ethyl trichloroacetoacetate 1 with p -substituted aromatic aldehydes (Ph, 4-Me-C 6 H 4, 4-ClÞ 4,4-MeO−C 6H 4 ) or furfural, and urea or thiourea catalyzed by indium(III) bromide, in high yields, in this article.
Journal ArticleDOI
Reactions of CF3-enones with arenes under superelectrophilic activation: a pathway to trans-1,3-diaryl-1-CF3-indanes, new cannabinoid receptor ligands
Roman O. Iakovenko,Anna N. Kazakova,Vasiliy M. Muzalevskiy,Alexander Yu. Ivanov,Irina A. Boyarskaya,Andrea Chicca,Vanessa Petrucci,Jürg Gertsch,Mikhail Krasavin,Galina L. Starova,Andrey A. Zolotarev,Margarita S. Avdontceva,Valentine G. Nenajdenko,Aleksander V. Vasilyev +13 more
TL;DR: The obtained trans-1,3-diaryl-1-trifluoromethyl indanes were investigated as potential ligands for cannabinoid receptors CB1 and CB2 types and showed sub-micromolar affinity for both receptor subtypes with a 6-fold selectivity toward the CB2 receptor with no appreciable cytotoxicity toward SHSY5Y cells.
References
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Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model
TL;DR: In this paper, a new parametric quantum mechanical molecular model, AM1 (Austin Model l), based on the NDDO approximation, is described, in which the major weaknesses of MNDO, in particular failure to reproduce hydrogen bonds, have been overcome without any increase in computing time.
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Studies in Chemotherapy. VIII. Methionine and Purine Antagonists and their Relation to the Sulfonamides1
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The mechanisms of heterocyclic ring closures
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Trifluoroacetylation of unsymmetrical ketone acetals. A convenient route to obtain alkyl side chain trifluoromethylated heterocycles
Helio G. Bonacorso,Marcos A. P. Martins,Sandra R. T. Bittencourt,Rogerio V. Lourega,Nilo Zanatta,Alex F. C. Flores +5 more
TL;DR: In this paper, a method to obtain β-alkyl-β-methoxyvinyl trifluoromethyl ketones from the regiospecific acylation of kinetic enol ether generated in situ is reported.