Journal ArticleDOI
Deoxynivalenol fatty acid and glucoside conjugates
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In this article, the synthesis of 10 conjugates of the mycotoxin 4-deoxynivalenol (DON) is described, including eight fatty acid esters and two glucosides.Abstract:
The synthesis of 10 conjugates of the mycotoxin 4-deoxynivalenol (DON) is described. The compounds synthesized include eight fatty acid esters and two glucosides. Fattyacid esters of DON were synthesized at positions 3 and 15 by reaction of DON with the appropriate acid chlorides in the presence of pyridine, while the glucosides were obtained by a Koenigs-Knorr reaction with acetobromoglucose. HPLC methods for the analysis of these compounds are also described.read more
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Journal ArticleDOI
Detoxification of the Fusarium Mycotoxin Deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana
Brigitte Poppenberger,Franz Berthiller,Doris Lucyshyn,Tobias Sieberer,Rainer Schuhmacher,Rudolf Krska,Karl Kuchler,Josef Glössl,Christian Luschnig,Gerhard Adam +9 more
TL;DR: The isolation and characterization of a gene from Arabidopsis thaliana encoding a UDP-glycosyltransferase that is able to detoxify deoxynivalenol is reported, and it is shown that this enzymatic reaction inactivates the mycotoxin.
Journal ArticleDOI
The Ability to Detoxify the Mycotoxin Deoxynivalenol Colocalizes With a Major Quantitative Trait Locus for Fusarium Head Blight Resistance in Wheat
Marc Lemmens,Uwe Scholz,Franz Berthiller,Chiara Dall'Asta,Andrea Koutnik,Rainer Schuhmacher,Gerhard Adam,Hermann Buerstmayr,Á. Mesterházy,Rudolf Krska,Peter Ruckenbauer +10 more
TL;DR: It is concluded that resistance to DON is important in the FHB resistance complex and hypothesize that Qfhs.ndsu-3BS either encodes a DON-glucosyl-transferase or regulates the expression of such an enzyme.
Journal ArticleDOI
Masked mycotoxins: determination of a deoxynivalenol glucoside in artificially and naturally contaminated wheat by liquid chromatography-tandem mass spectrometry.
TL;DR: The first report on the natural occurrence of a glucoside of deoxynivalenol in Fusarium-infected wheat and maize indicates the importance to consider both DON and DON-3-glucoside with regard to food and feed safety.
Journal ArticleDOI
Mycotoxins in cereals and related foodstuffs: A review on occurrence and recent methods of analysis
TL;DR: For the first time a review is done about mycotoxins occurrence in cereals and derived products published in the last years, together with the recent improvements regarding methods for their quantification.
Journal ArticleDOI
Trichothecenes in cereal grains.
Nora A. Foroud,François Eudes +1 more
TL;DR: A brief summary of the trichothecene synthesis in Fusarium species, their toxicity in plants and humans, followed by the current methods of screening and breeding for resistance to FHB and trichothcene accumulation are provided.