Journal ArticleDOI
Determination of lacidipine from urine by HPTLC using off-line SPE.
TLDR
The proposed method was found to be useful for the routine analysis of pharmaceuticals and pharmacokinetic studies in human urine samples and showed good linear relationship over the concentration range 10-80 ng.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2002-05-15. It has received 26 citations till now. The article focuses on the topics: Solid phase extraction & Thin-layer chromatography.read more
Citations
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Journal ArticleDOI
Quantitative determination of the calcium channel antagonists amlodipine, lercanidipine, nitrendipine, felodipine, and lacidipine in human plasma using liquid chromatography-tandem mass spectrometry
TL;DR: A sensitive and specific liquid chromatography-tandem mass spectrometric method has been developed and validated for the quantification of the five 1,4-dihydropyridine calcium channel antagonists amlodipine, lercanidipine and nitrendipine in human plasma, with good linearity and accuracy.
Journal ArticleDOI
Thin Layer Chromatographic Analysis of Biological Samples. A Review
Joseph Sherma,Bernard Fried +1 more
TL;DR: The use of thin layer chromatography (TLC) for the analysis of biological samples of particular interest to biologists, biochemists, hematologists, immunologists, medical diagnosticians, and molecular biologists is discussed in this article.
Journal ArticleDOI
Ultra-performance liquid chromatography-tandem mass spectrometry for the determination of lacidipine in human plasma and its application in a pharmacokinetic study.
TL;DR: A selective, rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of lacidipine in human plasma and successfully applied to a clinical pharmacokinetic study in healthy volunteers following oral administration.
Journal ArticleDOI
Development of a supercritical fluid chromatography-tandem mass spectrometry method for the determination of lacidipine in beagle dog plasma and its application to a bioavailability study.
TL;DR: In this paper, a simple liquid-liquid extraction method with tert-butyl methyl ether was used for the determination of lacidipine in beagle dog plasma with nimodipine as internal standard.
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Development of high performance liquid chromatography method for buspirone in rabbit serum: Application to pharmacokinetic study.
Ramesh Gannu,Shravan Kumar Yamsani,Chinna Reddy Palem,Vamshi Vishnu Yamsani,Harshini Kotagiri,Madhusudan Rao Yamsani +5 more
TL;DR: The method was successfully applied for pharmacokinetic study of buspirone after application of reservoir based transdermal therapeutic system of BUSP to rabbits and was found to be precise, accurate, and specific during the study.
References
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Journal ArticleDOI
Investigation into lacidipine and related metabolites by high-performance liquid chromatography—mass spectrometry
TL;DR: In this article, the main biotransformation products of lacidipine, a new antihypertensive drug, were characterized using HPLC-MS and particle beam interfaces.