Development of cell mediated immunity to flagellar antigens and acquired resistance to infection by Trypanosoma cruzi in mice
TLDR
These experiments suggested that the macrophage may have an important role in the early phases of infection particularly when nonspecific stimulation is associated with specific sensitization.Abstract:
Modulation by BCG and/or cyclophosphamide of sensitization of mice with flagellar fraction (a tubulin-enriched fraction) prevented death of mice challenged with T. cruzi CL strain trypomastigotes recovered from Vero cells. A methodology was ceveloped to assay specific antigens and to determine optimal doses for sensitization and elicitation of DTH in mice. CL strain is predominantly myotropic strain which does not produce important parasitism of mononuclear phagocyte cells; these cells appear to control infection when activated in vivo. Maximum protection was seen in this study when BCG and cyclophosphamide were associated, but protection was observed also when cyclophosphamide, that prevents supressor T cells, was applied 2 days before flagellar fraction sensitization in normal mice. These experiments suggested that the macrophage may have an important role in the early phases of infection particularly when nonspecific stimulation is associated with specific sensitization. A correlation betwen delayed hypersensitivity to parasite antigens and protection was observed.read more
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In Vitro Antileishmanial Activity of Essential Oil of Vanillosmopsis arborea (Asteraceae) Baker.
Aracélio Viana Colares,Fernando Almeida-Souza,Noemi Nosomi Taniwaki,Celeste da Silva Freitas de Souza,José Galberto Martins da Costa,Kátia da Silva Calabrese,Ana Lucia Abreu-Silva +6 more
TL;DR: Evidence is given that both VAEO and α-bisabolol have potential as new therapeutic agents against leishmaniasis.
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Canine visceral leishmaniosis in Anastácio, Mato Grosso do Sul state, Brazil.
V.M.C.L. Cortada,M.E.C. Doval,M.A.A. Souza Lima,Elisa Teruya Oshiro,C.R.V. Meneses,Ana Lucia Abreu-Silva,E. Cupolilo,C. S. F. Souza,Flávia de Oliveira Cardoso,T Zaverucha do Valle,Reginaldo Peçanha Brazil,Kátia da Silva Calabrese,S. C. Gonçalves da Costa +12 more
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Characterization and cytochemical localization of an ATP diphosphohydrolase from Leishmania amazonensis promastigotes.
Elaine Soares Coimbra,S. C. Gonçalves-Da-Costa,Suzana Corte-Real,F. G. R. De Freitas,A. C. Durão,C. S. F. Souza,M. I. Silva-Santos,Eveline Gomes Vasconcelos +7 more
TL;DR: It is proposed that L. amazonensis ATP diphosphohydrolase may participate in the salvage pathway of nucleosides, and Calcium was the best activating metal ion for both ATPase and ADPase activities.
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Role of T lymphocytes in the resistance and immunopathology of experimental Chagas' disease. I. Histopathological studies.
TL;DR: In this paper, the authors showed that T-dependent immune response controls parasite invasion, leading undesirable immunopathological effects, such as cellular inflammatory lesions, in mice infected with T. cruzi.
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Leishmania (Leishmania) infantum/chagasi: Histopathological aspects of the skin in naturally infected dogs in two endemic areas.
Kátia da Silva Calabrese,V.M.C.L. Cortada,Maria Elizabeth Cavalheiros Dorval,M.A.A. Souza Lima,Elisa Teruya Oshiro,C. S. F. Souza,Mariana Silva-Almeida,Letícia Pereira Carvalho,S. C. Gonçalves da Costa,Ana Lucia Abreu-Silva +9 more
TL;DR: There is a difference in the skin lesion patterns of dogs with leishmaniasis that is directly related to the endemic area where the animals live, and the skin of dogs presented a remarkable inflammatory reaction composed mainly of plasma cells, lymphocytes and very few parasites.