Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
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TLDR
The findings suggest that diabetes is an independent predictor of mortality from cancer of the colon, pancreas, female breast, and, in men, of the liver and bladder.Abstract:
Several studies have suggested that diabetes mellitus may alter the risk of developing a variety of cancers, and the associations are biologically plausible. To learn more about the relation between diabetes and cancer mortality, the authors examined associations with selected cancers in a large, prospective US cohort of 467,922 men and 588,321 women who had no reported history of cancer at enrollment in 1982. After 16 years of mortality follow-up, diabetes was significantly associated with fatal colon cancer in men (multivariate relative risk (RR) = 1.20, 95% confidence interval (CI): 1.06, 1.37) and women (RR = 1.24, 95% CI: 1.07, 1.43) and with pancreatic cancer in men (RR = 1.48, 95% CI: 1.27, 1.73) and women (RR = 1.44, 95% CI: 1.21, 1.72). For men, diabetes was significantly associated with liver cancer (RR = 2.19, 95% CI: 1.76, 2.72) and bladder cancer (RR = 1.43, 95% CI: 1.14, 1.80). In addition, diabetes was significantly associated with breast cancer in women (RR = 1.27, 95% CI: 1.11, 1.45). These associations were not explained by high body mass. Our findings suggest that diabetes is an independent predictor of mortality from cancer of the colon, pancreas, female breast, and, in men, of the liver and bladder.read more
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Diabetes mellitus, fasting glucose, and risk of cause-specific death.
Sreenivasa Rao Kondapally Seshasai,Stephen Kaptoge,Alexander J. Thompson,Emanuele Di Angelantonio,Pei Gao,Nadeem Sarwar,Peter H. Whincup,Kenneth J. Mukamal,Richard F. Gillum,Ingar Holme,Inger Njølstad,Astrid E. Fletcher,Peter M. Nilsson,Sarah Lewington,Rory Collins,Vilmundur Gudnason,Simon G. Thompson,Naveed Sattar,Elizabeth Selvin,Frank B. Hu,John Danesh +20 more
TL;DR: In addition to vascular disease, diabetes is associated with substantial premature death from several cancers, infectious diseases, external causes, intentional self-harm, and degenerative disorders, independent of several major risk factors.
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Edward Giovannucci,David M. Harlan,Michael C. Archer,Richard M. Bergenstal,Susan M. Gapstur,Laurel A. Habel,Michael Pollak,Judith G. Regensteiner,Douglas Yee +8 more
TL;DR: A consensus statement of experts assembled jointly by the American Diabetes Association and the American Cancer Society reviews the state of science concerning the association between diabetes and cancer incidence or prognosis and whether diabetes treatments influence risk of cancer or cancer prognosis.
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Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies.
Rachel R. Huxley,Alireza Ansary-Moghaddam,A Berrington de González,Federica Barzi,M N Woodward +4 more
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Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-Analysis
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References
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Regression models and life tables (with discussion
TL;DR: The drum mallets disclosed in this article are adjustable, by the percussion player, as to balance, overall weight, head characteristics and tone production of the mallet, whereby the adjustment can be readily obtained.
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Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study
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TL;DR: A strong positive association was observed between IGF-I levels and prostate cancer risk, independent of baseline prostate-specific antigen levels, which may have implications for risk reduction and treatment.
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Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3
Jing Ma,Michael Pollak,Edward Giovannucci,June M. Chan,Yuzhen Tao,Charles H. Hennekens,Meir J. Stampfer +6 more
TL;DR: Ass associations of plasma levels of IGF-I and IGFBP-3 with the risk of colorectal cancer are suggested to be consistent during the first and the second 7-year follow-up intervals and among younger and older men.