Journal ArticleDOI
Dichloroacetic acid improves in vitro myocardial function following in vivo endotoxin administration
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The data show that DCA aguments myocardial performance in hearts from endotoxin-injected rats, and it restores the depressed ATP concentration to normal levels.About:
This article is published in Journal of Critical Care.The article was published on 1986-03-01. It has received 23 citations till now. The article focuses on the topics: Dichloroacetic acid.read more
Citations
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Journal ArticleDOI
The pharmacology of dichloroacetate.
TL;DR: Despite its potential toxicity and limited clinical experience, DCA and its derivatives may prove to be useful in probing regulatory aspects of intermediary metabolism and in the acute or chronic treatment of several metabolic disorders.
Journal ArticleDOI
Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis.
TL;DR: Results of the studies on rat muscle, liver, heart, brain, and plasma suggest that there is no evidence of bioenergetic failure in these septic tissues and that the increase in lactate production is not necessarily due to cellular hypoxia.
Journal ArticleDOI
Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate.
Robert M. Bersin,Christopher L. Wolfe,Michael Kwasman,Deborah Lau,Cindy Klinski,Kevin Tanaka,Payman Khorrami,George N. Henderson,Teresa De Marco,Kanu Chatterjee +9 more
TL;DR: Dichloroacetate administration stimulates myocardial lactate consumption and improves left ventricular mechanical efficiency and does not change with dobutamine administration, suggesting that these agents may be complementary in the treatment of congestive heart failure.
Journal ArticleDOI
Dichloroacetate as metabolic therapy for myocardial ischemia and failure
TL;DR: Although long-term studies are lacking, short-term parenteral administration of DCA appears to be safe and capable of significantly improving myocardial function in conditions of limited oxygen availability by increasing the efficient conversion of myocardIAL substrate fuels into energy.
Journal ArticleDOI
Dichloroacetate in the treatment of lactic acidosis.
TL;DR: An open, prospective evaluation of the effects of dichloroacetate on morbidity and survival time was done in 29 pediatric and adult patients with lactic acidosis, finding median survival time among responders was 60 hours, compared to 26 hours among nonresponders.
References
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Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Principles and Procedures of Statistics.
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Methods of Enzymatic Analysis
TL;DR: Methods of enzymatic analysis, Methods of enzymes analysis, the authors, Methods of enzyme analysis, enzymatics, methods of enzymes, and methods of analysis, method of enzymes.
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Profound but Reversible Myocardial Depression in Patients with Septic Shock
Margaret M. Parker,James H. Shelhamer,Stephen L. Bacharach,Michael V. Green,Charles Natanson,Terri M. Frederick,Barbara A. Damske,Joseph E. Parrillo +7 more
TL;DR: To characterize the role of cardiac function in septic shock, serial radionuclide cineangiographic and hemodynamic evaluations were done on 20 patients with documented septicShock, finding that nonsurvivors had normal initial ejection fractions and ventricular volumes that did not change during serial studies.