Showing papers in "The American Journal of Medicine in 1982"

TL;DR: A number of clinical studies have been performed in an attempt to dissect the particular component or components of the diabetic state responsible for these early elevations in glomerular filtration rate, and no single factor appears to account fully for this phenomenon.

TL;DR: It is suggested that continuing antibiotic therapy reduces early bacterial infections in patients with persistent fever and granulocytopenia and that empiric antifungal therapy also appears necessary to prevent fungal superinfections and to control clinically undetected fungal invasion.

TL;DR: The data suggest that biases in patient selection may irretrievably weight the outcome of HCts in favor of new therapies, and that RCTs may miss clinically important benefits because of inadequate attention to sample size.

TL;DR: Good control of blood sugar in diabetic patients is a desirable goal in the prevention of certain infections (Candida vaginitis, for example) and to ensure maintenance of normal host defense mechanisms that determine resistance and response to infection.

TL;DR: To study the relative contributions of scientific and commercial sources of information, two index drugs were chosen, whose pharmacologic effects have been shown by controlled studies to be minimal or not significantly different from those of nonprescription (over-thecounter) preparations, but which are heavily advertised as being effective.

TL;DR: In selected patient, diagnostic tests such as blood chemistries, electrocardiograms, electroencephalograms, and Holter monitoring provided crucial information, and CT scans identified new brain tumors in four patients with focal neurologic presentations.

TL;DR: In this article, the authors describe the relationship between the major depressive disorder and somatization and develop a conceptual; model that elucidates the mechanism behind the selective perception and focus by the patient on the somatic manifestations of depression.

TL;DR: Randomized controlled clinical trials (RCTs) are among the most difficult and expensive of scientific studies and have their costs in the most precious of commodities, human suffering.

TL;DR: The DEALE method is used to obtain approximations of quality-adjusted life expectancy and the application of the method in a quantitative analysis of a clinical decision is illustrated.

TL;DR: The abnormalities of respiratory movements may be reliable clinical signs of inspiratory muscle fatigue, particularly when accompanied by tachypnea and hypercapnia.

TL;DR: A simple approximation of life expectancy (the "DEALE") that is based on the assumption that survival follows a simple declining exponential function is described and it is shown that this approximation estimates life expectancy accurately for the great majority of clinical problems.

TL;DR: In this paper, the authors studied the impact of fine-needle aspiration biopsy on the management of patients with solitary thyroid nodules, and found that fine needle aspiration appears to be safe, reliable, and cost-effective.

TL;DR: Suggests are made for improved management of patients at high risk for invasive fungal infections in patients undergoing intensive induction chemotherapy, based upon recognition of the clinical settings in whichfungal infections occur and the aggressive use of invasive diagnostic procedures.

TL;DR: Acyclovir, an acrylic purine nucleoside analog, is a highly potent inhibitor of herpes simplex virus, types 1 and 2, and varicella zoster virus, and has extremely low toxicity for the normal host cells.

TL;DR: So-called essential hypernatremia due to primary resetting of the osmostat has been postulated, but unambiguous evidence for such an entity has not yet been reported.

TL;DR: The possible etiologic factors underlying the immunologic abnormalities in the male homosexual population studied and the role of an altered immune system in the development of and the fulminant course of Kaposi's sarcoma in these patients are discussed.

TL;DR: After an average follow-up interval of three and a half years, 125 patients with occupational asthma due to red cedar exposure were re-examined and early diagnosis and removal from exposure were found to be associated with recovery.

TL;DR: In patients with pneumonia or in elderly patients, an increased awareness of the possibility of pulmonary embolism and more frequent use of lung scanning and pulmonary angiography may increase the accurate clinical diagnosis of pulmonaryembolism.

TL;DR: The findings suggest that renal and absorptive hypercalciuria may not be distinct entities but rather the two extremes of a continuum of behavior.

TL;DR: The most common adverse reaction was a low incidence of peripheral vein irritation; no serious toxicity could be definitely attributed to acyclovir treatment even in these seriously ill patients.

TL;DR: It is suggested that leukocytic pyrogen, in addition to producing fever, also stimulates non-hypothalamic cells involved in aspects of the acute-phase response, and may be an important mechanism for host defenses.

TL;DR: The benefits of high plasma concentrations in the acute phase of this life-threatening disease appear to outweigh the risks, particularly in view of the increasing resistance of Plasmodium falciparum to quinine in Southeast Asia.

TL;DR: It is suggested that adventitial eosinophilic infiltrate may be responsible for spontaneous coronary artery dissection.

TL;DR: Abnormalities of renal prostaglandins are evident in various clinical disorders of renal function including hypertension, ureteral obstruction, Bartter syndrome, hypokalemic nephropathy and drug-induced disorders of water metabolism.

TL;DR: The results of 24-hour continuous electrocardiographic monitoring of 23 patients with documented sleep apnea syndrome suggest that the prevalence of serious arrhythmias and conduction disturbances during sleep in patients with the sleep Apnea syndrome is much lower than previously reported.

TL;DR: Three hundred and seventy-eight hospitalized patients undergoing nonrenal angiography were evaluated for subsequent changes in renal function and recommended a screening serum creatinine determination 24 to 48 hours after infusion of angiographic contrast material in azotemic patients.

TL;DR: The number of episodes of hypopnea of desaturation did not significantly increase, although the degree of des saturation increased after flurazepam ingestion, and total sleep time significantly increased, but could not account for the increased number of events.

TL;DR: All five patients with PA and acute abdomens required operative intervention and all had gross evidence of mesenteric arteritis with large ischemic segments resulting in infarction and perforation and died in contrast to only two (18 percent) of the 11 PA patients without abdominal involvement.

TL;DR: An approach using serologic tests as a screen is suggested to determine whether more specialized tests for Legionnaire's disease should be introduced into a hospital without previously recognized cases of Legionnaires' disease.

TL;DR: New information based upon observations in patients and limited experimental studies in animals suggests that skeletal muscle cells, under conditions of certain specific electrolyte derangement, show a common pattern of changes characterized by abnormal electrogenesis and elevation of intracellular Na concentration that could well set the stage for irreversible cellular injury by another important mechanism.