Journal ArticleDOI
Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas
Ettore Mearini,Rita Romani,Luigi Mearini,Cinzia Antognelli,Alessandro Zucchi,Tiziano Baroni,Massimo Porena,Vincenzo Nicola Talesa +7 more
TLDR
The role of the glyoxalases in detoxifying cytotoxic methylglyoxal (MG) in bladder cancer is confirmed and differing levels of GI activity level and gene expression between the SBC and IBC samples could help in their differential diagnosis.About:
This article is published in European Journal of Cancer.The article was published on 2002-09-01. It has received 35 citations till now. The article focuses on the topics: Glyoxalase system & Lactoylglutathione lyase.read more
Citations
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The glyoxalase pathway: the first hundred years... and beyond.
TL;DR: The aim of the present review is to show the evolution of thought regarding the glyoxalase pathway since its discovery 100 years ago, the current knowledge on the glyxalase enzymes and their recognized role in the control of glycation processes.
Journal ArticleDOI
Glyoxalase in tumourigenesis and multidrug resistance
Paul J. Thornalley,Naila Rabbani +1 more
TL;DR: The aim of this review is to assess the evidence for the involvement of the glyoxalase system in tumour growth and multidrug resistance and the importance of the Glyoxalases system as a target for anticancer drug development and a source of biomarkers for tumour diagnosis.
Journal ArticleDOI
Bovine mammary gene expression profiling using a cDNA microarray enhanced for mammary-specific transcripts.
Steven P. Suchyta,Sue Sipkovsky,Robert G. Halgren,Rachael Kruska,Michael D. Elftman,Miriam Weber-Nielsen,Michael J. VandeHaar,Lan Xiao,Robert J. Tempelman,Paul M. Coussens +9 more
TL;DR: A putative set of 16 genes being preferentially expressed in developing mammary gland are identified using the BMAM microarray to elucidate the genes and pathways associated with bovine lactation and involution and to use these as a model for human mammary glands development as it relates to human breast cancer risks.
Journal ArticleDOI
Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer
TL;DR: This review will examine studies regarding the effects of MG on cancer onset and progression and discuss their controversies, and the utilisation of inhibitors and MG scavengers will be addressed in the context of MG-mediated stress blockade for cancer therapy.
Journal ArticleDOI
Glyoxalase II, a Detoxifying Enzyme of Glycolysis Byproduct Methylglyoxal and a Target of p63 and p73, Is a Pro-survival Factor of the p53 Family
Yang Xu,Xinbin Chen +1 more
TL;DR: It is postulated that GLX2 serves as a pro-survival factor of the p53 family and plays a critical role in the normal development and in the pathogenesis of various human diseases, including cancer, diabetes, and neurodegenerative diseases.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose.
TL;DR: Alpha-Oxoaldehydes were formed in early glycation from the degradation of glucose and Schiff's base adduct, which suggests that short periods of hyperglycaemia, as occur in impaired glucose tolerance, may be sufficient to increase the concentrations of alpha-oxoaldeHydes in vivo.
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The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.
TL;DR: Investigation has brought new developments in the involvement of the glyoxalase in cell growth and vesicle mobilization, with increasing evidence of changes in the gly oxalase system during tumor growth and diabete mellitus, particularly relating to the development of associated clinical complications.
Glutathione : chemical, biochemical, and medical aspects
TL;DR: The author index refers to the Pyridine Nucleotide Derivatives Index, which describes the biochemical and physiological properties of the molecule as well as the pharmacological and nutritional aspects of Glutathione.