Journal ArticleDOI
Dosage Schedule and Pharmacokinetics in Chemotherapy
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TLDR
The relationships between the chemotherapeutical dosage schedule and the pharmacokinetical constants and the adsorption constants α and β, and the minimum inhibition concentration μ of the bacteriostatic drug are formulated.Abstract:
The relationships between the chemotherapeutical dosage schedule (supporting dose D , ratio of initial to supporting dose D + / D , dosing interval τ ) and the pharmacokinetical constants k 1 , k 2 , and V d , the adsorption constants α and β , and the minimum inhibition concentration μ of the bacteriostatic drug, are formulated.read more
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Pharmacokinetics of topically applied ophthalmic drugs
TL;DR: Pharmacokinetics includes the quantitation of such elements of drug bioavailability as tear dilution, drug binding, and vehicle effects; factors affecting corneal absorption and subsequent tissue distribution; dosage form effects; and pathways of elimination.
Journal ArticleDOI
Blood Levels of Drug at the Equilibrium State after Multiple Dosing
TL;DR: This work has shown that when a fixed dose of drug is administered in a fixed multiple-dose regimen, the blood levels of drug eventually reach a steady state in which the blood level time curve during any dosage interval is the same as it is in the preceding and in the following dosage interval.
Journal ArticleDOI
Drug Dosage in Renal Disease
TL;DR: It is shown how individual drug elimination parameters in patients with renal disease can be estimated from the patient’s creatinine clearance or serum creatInine concentration by means of a simple nomogram which describes the elimination rate of the drug as a fraction of its normal elimination rate constant.
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Continous intravenous infusion and multicompartment accumulation
TL;DR: The pharmacokinetics of intravenous infusion is studied for models assuming more than one body compartment, and the rate of which decreases exponentially to the proper steady-state rate is studied.
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Journal Article
Streptomycin in the blood; chemical determinations after single and repeated intramuscular injections.
TL;DR: From the results obtained, it is possible to calculate with reasonable accuracy the serum concentrations of the drug in man after intramuscular injection of streptomycin in doses ranging from 4,000 to 20,000 γ/ kg.