Dose-dependent effects of short-term methylprednisolone on myocardial infarct extent, scar formation, and ventricular function.
TLDR
Etude faite chez le chien, les doses eleves de methylprednisolone, mais pas les doses faibles, provoquent une cicatrice nettement moins epaisse, avec reduction of the fonction regionale, sans modification du contenu en collagene.Abstract:
Etude faite chez le chien. Les doses eleves de methylprednisolone, mais pas les doses faibles, provoquent une cicatrice nettement moins epaisse, avec reduction de la fonction regionale, sans modification du contenu en collageneread more
Citations
More filters
Journal ArticleDOI
Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.
Marc A. Pfeffer,Eugene Braunwald +1 more
TL;DR: The extent of ventricular enlargement after infarction is related to the magnitude of the initial damage to the myocardium and, although an increase in cavity size tends to restore stroke volume despite a persistently depressed ejection fraction, ventricular dilation has been associated with a reduction in survival.
Book ChapterDOI
Ventricular Remodeling after Myocardial Infarction
TL;DR: The extent of ventricular enlargement after infarction is related to the magnitude of the initial damage to the myocardium and, although an increase in cavity size tends to restore stroke volume despite a persistently depressed ejection fraction, ventricular dilation has been associated with a reduction in survival.
Journal ArticleDOI
Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities.
Sang Bing Ong,Sauri Hernández-Reséndiz,Gustavo E. Crespo-Avilan,Regina T. Mukhametshina,Xiu Yi Kwek,Hector A. Cabrera-Fuentes,Derek J. Hausenloy +6 more
TL;DR: An overview of the multiple players (and their dynamic roles) involved in the complex inflammatory response to AMI and subsequent LV remodeling is provided, and future opportunities for targeting inflammation as a therapeutic strategy for limiting MI size, preventing adverse left ventricular remodeling, and reducing heart failure in AMI patients are highlighted.
Journal ArticleDOI
Cardiac Release of Cytokines and Inflammatory Responses in Acute Myocardial Infarction
Franz-Josef Neumann,Ilka Ott,Meinrad Gawaz,Gert Richardt,Heidi Holzapfel,Marianne Jochum,Albert Schömig +6 more
TL;DR: Cardiac neutrophil activation with signs of endothelial injury and a release of the proinflammatory cytokines IL-8 and IL-6 are demonstrated as evidence of cardiac inflammatory responses in reperfused acute MI.
Journal ArticleDOI
Limitation of myocardial infarct expansion by reperfusion independent of myocardial salvage.
Judith S. Hochman,H Choo +1 more
TL;DR: The results of this study in the rat preparation suggest a beneficial effect of "late" reperfusion on infarct expansion independent of myocardial salvage, which could mean the period after myocardIAL infarction during which a patient can be considered for thrombolytic therapy or reperfusions by percutaneous transluminal coronary angioplasty could be greatly prolonged.
References
More filters
Journal ArticleDOI
Determination of hydroxyproline.
TL;DR: A critical review is given of hydroxyproline analysis, finding a procedure which is faster and more sensitive than the former one and as reliable.
Journal ArticleDOI
Glucocorticosteroid Therapy: Mechanisms of Action and Clinical Considerations
TL;DR: The administration of glucocorticosteroids results in a wide range of effects on inflammatory and immunologically mediated disease processes, and the corticosteroid regimen should be adjusted to attain maximal therapeutic benefit with minimal adverse side effects.
Journal ArticleDOI
Infarct Expansion Versus Extension: Two Different Complications of Acute Myocardial Infarction
TL;DR: The study shows that expansion is a common complication of acute myocardial infarction that can worsen cardiac function through left ventricular dilatation and can mimic or possibly cause infarct extension and is usually a result of hypoperfusion.
Journal ArticleDOI
The Histopathologic Evolution of Myocardial Infarction
TL;DR: Waviness appears to be due to ischemic injury of fibers and may be the earliest light-microscopic change in evolving myocardial infarction, while myocytolysis does not appear to be related to ischemia per se.
Related Papers (5)
Deleterious effects of methylprednisolone in patients with myocardial infarction.
Roberts R,DeMello,Sobel Be +2 more