Double isotope derivative assay of aldosterone in biological extracts.
TLDR
This report includes a detailed description of the method, assay results for human urine and dog adrenal vein plasma, and a critical evaluation of the specificity, precision, and accuracy of this technique.About:
This article is published in Journal of Biological Chemistry.The article was published on 1960-06-01 and is currently open access. It has received 574 citations till now. The article focuses on the topics: Derivative (chemistry).read more
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Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome.
TL;DR: In this article, a new syndrome, characterized by hypertrophy and hyperplasia of the juxtaglomerular apparatus of the kidneys, aldosteronism resulting from adrenal cortical hyper-plasia, and persistently normal blood pressure is described in two patients.
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17-hydroxylation deficiency in man.
TL;DR: The biosynthesis of steroid hormones 1 requires a number of hydroxylating enzymes and 17a-Hydroxylase activity is present in patients with congenital adrenal hyperplasia because of the increases in secretion of androgens and excretion of preg-nanetriol.
Journal ArticleDOI
Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. 1962.
TL;DR: A new syndrome, characterized by hypertrophy and hyperplasia of the juxtaglomerular apparatus of the kidneys, aldosteronism resulting from adrenal corticalhyperplasia, and persistently normal blood pressure is described in two patients.
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Cushing's syndrome: A review of diagnostic tests
TL;DR: Under certain conditions, the basal state daily urine excretion of 17-hydroxycorticosteroids and 17-ketogenic steroids, the insulin tolerance test, and the metyrapone test may be useful in the definitive or differential diagnosis of Cushing's syndrome.
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Primary aldosteronism: diagnosis, localization, and treatment.
Myron H. Weinberger,Clarence E. Grim,John W. Hollifield,David C. Kem,Arunabha Ganguly,Norman J. Kramer,Heun Y. Yune,H. N. Wellman,John P. Donohue +8 more
TL;DR: Four localizing techniques were compared in 51 patients with primary aldosteronism and Adrenalectomy resulted in normal blood pressure in 59, improvement in 25, and no change in 16%, while of the 26 patients with an anomalous postural decrease in plasma aldosterone, 88% had a unilateral lesion.
References
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Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.
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Evaluation of Silber-Porter Procedure for Determination of Plasma Hydrocortisone
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Physicochemical estimation of aldosterone in urine.
Robert Neher,Albert Wettstein +1 more