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Open AccessJournal ArticleDOI

Dual control of relaxation. Its role in the ventricular function in the mammalian heart.

Dirk L. Brutsaert, +2 more
- 01 Nov 1980 - 
- Vol. 47, Iss: 5, pp 637-652
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TLDR
A toujours plus de chaleur dans le coeur qu' en aucun autre endroit du corps as discussed by the authors is capable of faire que, s'il entre quelque goutte de sang en ses concavite's, elle s'enfle promptement and se dilate, ainsi que font ge'neralement toutes les liqueurs, lorsqu'on les laisse tomber gouttes a goustte en quelques vaisseau qui est fort ch
Abstract
II y a toujours plus de chaleur dans le coeur qu' en aucun autre endroit du corps. Cette chaleur est capable de faire que, s'il entre quelque goutte de sang en ses concavite's, elle s'enfle promptement et se dilate, ainsi que font ge'ne'ralement toutes les liqueurs, lorsqu'on les laisse tomber goutte a goutte en quelque vaisseau qui est fort chaud. Ces gouttes se rare'fient et se dilatent, a cause de la chaleur qu'ellesy trouvent, au moyen de quoi, faisant enfler tout le coeur, elles poussent et ferment les cinq petites portes*; et continuant a se rare'fier de plus en plus, elles poussent et ouvrent les six autres petites portes'f qui sont aux entrees des deux autres vaisseaux par ou elles sortent; le coeur, incontinent apres, se de'senfle.

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Citations
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Evaluation of Diastolic Filling of Left Ventricle in Health and Disease: Doppler Echocardiography Is the Clinician’s Rosetta Stone

TL;DR: A simplified approach to understanding the process of diastolic filling of the left ventricle and interpreting the Doppler flow velocity curves as they relate to this process is presented.
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Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review

TL;DR: The extent of hypertrophy is believed to be the principal determinant of the impaired left ventricular relaxation and increased chambers stiffness that characterize diastole in hypertrophic cardiomyopathy.
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Hypertrophic Cardiomyopathy Clinical Spectrum and Treatment

TL;DR: HCM is a heterogeneous disease genotypic, phenotypically, pathophysiologically, clinically, and therapeutically and in decisions on the management of these patients, it is important to recognize this heterogeneity and to direct therapy at the predominant abnormalities.
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The noninvasive assessment of left ventricular diastolic function with two-dimensional and Doppler echocardiography

TL;DR: Therapeutic intervention is directed toward normalizing loading conditions and improving the restrictive filling pattern, although this may not be feasible in certain heart diseases.
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Left ventricular filling dynamics: influence of left ventricular relaxation and left atrial pressure.

TL;DR: PRFR is determined by both the left atrial pressure and the left ventricular relaxation rate and should be used with caution as an index ofleft ventricular diastolic function.
References
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Journal ArticleDOI

Hemodynamic determinants of the time-course of fall in canine left ventricular pressure.

TL;DR: The present studies show that the time-course of isovolumic pressure fall subsequent to maximum negative dP/dt is exponential, independent of systolic stress and end-systolic fiber length, and minimally dependent on heart rate.
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Regional Myocardial Function during Acute Coronary Artery Occlusion and Its Modification by Pharmacologic Agents in the Dog

TL;DR: The results indicate the power of this approach, which provides continuous quantification of regional wall function in myocardial ischemia and during therapeutic interventions, and suggests a protective effect of this drug.
Journal ArticleDOI

Calcium transients in isolated amphibian skeletal muscle fibres: detection with aequorin.

TL;DR: There was a progressive reduction in both the amplitude and the rate of decline of the aequorin response during trains of isometric contractions, an observation consistent with the theory that Ca is redistributed from sites of release to sites of sequestration under such circumstances.
Journal ArticleDOI

Diastolic Properties of the Left Ventricle

TL;DR: Left ventricular pressure and volume during diastole reflect the interaction of ventricular elastic, viscous, and inertial properties, and the completeness of myocardial relazation, and may be impaired in the acutely ischemic ventricle.
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