Journal ArticleDOI
Effect of hypoxia on trophoblast in organ culture: A morphologic and autoradiographic study☆
TLDR
It is suggested that the cytotrophoblast proliferates under conditions of hypoxia in an attempt to repair damaged syncytium and that the findings mimic those frequently seen in placentas from toxemic patients.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1970-08-01. It has received 225 citations till now. The article focuses on the topics: Organ culture & Cytotrophoblast.read more
Citations
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Journal ArticleDOI
Pathology of the placenta.
TL;DR: The placenta has a considerable functional reserve capacity, easily repairs ischaemic damage, is able to compensate for toxic injury and does not appear to appear to age as mentioned in this paper.
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Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3
Isabella Caniggia,Homa Mostachfi,Jennifer Winter,Max Gassmann,Stephen J. Lye,Maciej Kuliszewski,Martin Post +6 more
TL;DR: Examination of placental expression of hypoxia-inducible factor-1 (HIF-1), a master regulator of oxygen homeostasis, determined that expression of Hif-1alpha subunit during the first trimester of gestation parallels that of TGFbeta(3), an inhibitor of extravillous trophoblast differentiation.
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Development of the placental villous tree and its consequences for fetal growth
TL;DR: Since transgenic mouse studies highlight the importance of trophoblast-derived transcription factors for placental villous (labyrinth) development, it is possible that the villous trophOBlast controls the orderly development of the underlying mesoderm and blood vessels into the fetal villi.
Journal ArticleDOI
Oxygen and placental villous development: origins of fetal hypoxia.
John Kingdom,Peter Kaufmann +1 more
TL;DR: These data suggest that the origin of fetal hypoxia in IUGR with absent end-diastolic flow in the umbilical arteries is due to a failure of oxygen transport from intervillous space to Umbilical vein.
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Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies.
TL;DR: The results indicate that oxidative damage to the trophoblast, induced by premature and widespread onset of the maternal placental circulation secondary to shallow trophOBlast invasion, is a key factor in early pregnancy loss.
References
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The maternal placental blood flow in normotensive and hypertensive women.
J. C. McClure Browne,N. Veall +1 more
TL;DR: A method has been evolved whereby the relative rates of maternal placental blood flow in normal and hypertensive women can be studied, the results being presented below.
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Histochemical observations on the human placenta.
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Morphogenesis of syncytiotrophoblast in vivo: an autoradiographic demonstration.
TL;DR: In an in vivo autoradiographic study of immature primate trophoblast, tritiated thymidine was first found only in nuclei of cytotrophoblast but after 22 hours, labeled nuclei appeared in syncytiotrophobasts as well.
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Choriodecidual and myometrial blood-flow.
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The ultrastructure of normal human first trimester placenta.
TL;DR: First trimester human placentae were studied with the electron microscope and a hypothesis is presented that the secretory granules may be the steroid hormones estrogen and progesterone.