Journal ArticleDOI
Effect of Immunization Against Rubella on Lactation Products. I. Development and Characterization of Specific Immunologic Reactivity in Breast Milk
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TLDR
The virus-specific immune response induced in human milk after immunization with rubella virus vaccine may be intimately linked with the reactivity in bronchial lymphoid tissue.Abstract:
The development of an immune response to rubella virus in milk, serum, and nasopharyngeal secretions was studied in lactating postpartum women after immunization with HPV-77 De5 or RA 27/3 live, attenuated rubella virus vaccine administered subcutaneously or intranasally. Over 69% of the women shed virus in milk after immunization. A predictable nasopharyngeal IgA and serum IgG antibody response to rubella virus was observed after subcutaneous or intranasal immunization with RA 27/3 vaccine. Little or no nasopharyngeal antibody response was seen after subcutaneous immunization with HPV-77 DE5 vaccine. A virus-specific IgA antibody response in milk was seen in all women. The presence of rubella virus in breast milk seemed to potentiate the peak levels of virus-specific antibody in the milk. Cellular immune reactivity to rubella virus in milk was observed in all vaccine groups. Thus, the virus-specific immune response induced in human milk after immunization with rubella virus vaccine may be intimately linked with the reactivity in bronchial lymphoid tissue.read more
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Book
Immunisation against infectious disease
TL;DR: The new edition of "Immunisation Against Infectious Disease" (the Green Book), presents the latest information on vaccines and vaccination procedures for all the vaccine preventable infectious diseases that may occur in the UK or in travellers going outside of the UK.
Book ChapterDOI
Chapter 5 – Human Milk*
TL;DR: This chapter reviews existing information on major aspects of the physiologic, nutritional, and bioactive components of human milk and recommends that in the absence of specific contraindications, healthy term infants should be exclusively breastfed or fed expressed breast milk.
Journal ArticleDOI
Measles-mumps-rubella vaccine and autistic spectrum disorder: report from the New Challenges in Childhood Immunizations Conference convened in Oak Brook, Illinois, June 12-13, 2000.
Neal A. Halsey,Susan L. Hyman +1 more
TL;DR: The available evidence does not support the hypothesis that MMR vaccine causes autism or associated disorders or IBD, and epidemiologic studies in Europe indicate no association between MMR vaccine and ASD.
Journal ArticleDOI
Human Milk Glycoproteins Protect Infants Against Human Pathogens
Bo Liu,David S. Newburg +1 more
TL;DR: Known biological roles of HMGPs that may contribute to the ability of human milk to protect neonates from disease are summarized.
Journal ArticleDOI
Postpartum Rubella Immunization: Association with Development of Prolonged Arthritis, Neurological Sequelae, and Chronic Rubella Viremia
TL;DR: Six women developed chronic long-term arthropathy after postpartum immunization against rubella and have had continuing chronic or recurrent arthralgia or arthritis for two to seven years after vaccination.
References
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Journal ArticleDOI
Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
Journal ArticleDOI
Origin of IgA-secreting plasma cells in the mammary gland.
TL;DR: Homing MN lymphoblasts are sensitive to antiserum to IgA plus complement, but not to other class-specific antisera, and under natural conditions it is likely that IgA precursor cells migrate to the mammary gland where they secrete antibodies which constitute an important defense mechanism of the newborn.
Journal ArticleDOI
Cellular kinetics of the intestinal immune response to cholera toxoid in rats.
N F Pierce,J. L. Gowans +1 more
TL;DR: The aims of this study were to find a regime of immunization with cholera toxoid in rats which would establish a high density of antitoxin containing cells (ACC) in the lamina propria of the intestine and to determine the origin of the ACC.
Journal ArticleDOI
Antibody-forming cells in human colostrum after oral immunisation.
Randall M. Goldblum,S. Ahlstedt,Barbro Carlsson,Lars Å. Hanson,Ulf Jodal,G. Lidin-Janson,A. Sohl-Åkerlund +6 more
TL;DR: The effect of gastrointestinal immunisation on the development of antibody-producing cells in colostrum of humans was examined and it was found that oral administration of a non-pathogenic strain of E. coli led to the rapid appearance of colostral cells producing antibodies against the O antigen of the organism.
Journal ArticleDOI
Antibody Response in Serum and Nasopharynx after Naturally Acquired and Vaccine-Induced Infection with Rubella Virus
TL;DR: Antibody response to rubella virus was studied in serum and nasopharyngeal secretions after natural infection, intranasal inoculation with RA-27/3 rubella vaccine and subcutaneous administration of HPV-77 DK/12 rubella-virus vaccine.