Journal ArticleDOI
Effect of lithium on thyroidal 131iodine uptake, its clearance, and circulating levels of triiodothyronine and thyroxine in lead-treated rats.
TLDR
The thyroidal biological half-life of 131I (Tbiol) was found to have clearly increased following the lead/lithium treatment, thus reflecting an increased retention of 131B, and a progressive decline of the circulating T3 and T4 levels following lead or lithium treatment was noticed.Abstract:
The influence of lead acetate (50 mg per kg body weight) on the 131iodine (131I) biokinetics (uptake and retention) in rat thyroid and serum levels of triiodothyronine (T3) as well as thyroxine (T4) was evaluated as a function of time and in combination with lithium treatment. The 2-h and 24-h uptake of 131I in the thyroid was stimulated significantly by lead treatment. The 24-h uptake showed a maximum stimulation after 4 months of lead treatment. Lithium supplementation, however, showed the opposite effect by reducing the iodine uptake, whereby the maximum decrease was noticed after 2 months of treatment. Further, simultaneous lead and lithium treatment resulted in an even more pronounced increase of 2-h 131I uptake with a maximum after 3 months. However, the 24-h uptake after 3 months and 4 months of treatment did not differ significantly from the lead treated reference groups. The thyroidal biological half-life of 131I (Tbiol) was found to have clearly increased following the lead/lithium treatment. Interestingly, the combined lead/lithium treatment applied for 4 months caused a further growth of Tbiol, thus reflecting an increased retention of 131I. A maximum increase of Tbiol was seen after 2 months of combined treatment. A progressive decline of the circulating T3 and T4 levels following lead or lithium treatment was noticed and was more pronounced after combined treatment.read more
Citations
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Journal ArticleDOI
Relationship of Thyroid Hormone Levels to Levels of Polychlorinated Biphenyls, Lead, p,p′- DDE, and Other Toxicants in Akwesasne Mohawk Youth
Lawrence M. Schell,Mia V. Gallo,Melinda Denham,Julia Ravenscroft,Anthony P. DeCaprio,David O. Carpenter +5 more
TL;DR: It appears that PCBs from breast milk obscure the relationship between prenatal PCB exposure and thyroid function by adding random variation in PCB levels, demonstrating a reduction in thyroid function in adolescents in relation to their current serum levels of PCBs.
Journal ArticleDOI
Impact of lead exposure on pituitary-thyroid axis in humans
Baljinder Singh,Vinod Chandran,H. K. Bandhu,Bhagwant Rai Mittal,Anish Bhattacharya,Surinder K. Jindal,Subhash Varma +6 more
TL;DR: The Pb-B levels of ≥2.4 μmole/l (50 μg/dl) could enhance the pituitary release of TSH without having any significant alterations in the circulating levels of T3 and T4.
Journal ArticleDOI
Relationship between blood cadmium, lead, and serum thyroid measures in US adults – the National Health and Nutrition Examination Survey (NHANES) 2007–2010
Juhua Luo,Michael Hendryx +1 more
TL;DR: It is suggested that thyroid function may be disrupted by both Cd and lead exposures in the general population and the specific roles of C d and lead exposure on thyroid axis may differ by sex.
Journal ArticleDOI
Zinc supplementation prevents liver injury in chlorpyrifos-treated rats.
Ajay Goel,Devinder K. Dhawan +1 more
TL;DR: Data clearly show the protective effects of zinc in animals subjected to organophosphate poisoning, which protected hepatocytes from the marked disruptions in the membranous organelles and narrowing/blocking of biliary channels, which was otherwise a common observation following chlorpyrifos treatment.
Journal ArticleDOI
Effects of zinc coadministration on lead toxicities in rats.
Fengyuan Piao,Fanyin Cheng,Haibo Chen,Gang Li,Xiance Sun,Shuang Liu,Toru Yamauchi,Kazuhito Yokoyama +7 more
TL;DR: It is suggested that Zn coadministration might alleviate toxic effects of Pb on the male reproductive system, whereas it could enhance the toxicity on thyroid function.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
Effect of Lithium on Thyroid Function
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Journal ArticleDOI
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Journal ArticleDOI
Thyroid abnormalities during lithium treatment.
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TL;DR: Thyroid function was evaluated in 150 Sardinian outpatients at different stages of lithium treatment, and the prevalence of specific antithyroid antibodies was positively correlated with age and duration of lithium Treatment, and was higher in women.
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