Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study.
TLDR
Nifedipine thus appears safe in patients with angina pectoris who have disorders of atrioventricular nodal conduction, and in those receiving beta-adrenergic blocking drugs.Abstract:
Intravenous nifedipine, a powerful calcium antagonist, had no obvious effect on atrioventricular conduction when administered to 11 patients during routine intracardiac electrophysiological studies. Verapamil on the other hand showed potent antiarrhythmic properties, depressing atrioventricular nodal conduction. Nifedipine thus appears safe in patients with angina pectoris who have disorders of atrioventricular nodal conduction, and in those receiving beta-adrenergic blocking drugs. There appear to be differential effects on the slow inward channels of cardiac cells with different 'calcium antagonists'.read more
Citations
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Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem
TL;DR: Nifedipine is a potent, long-acting vasodilator that has proved highly efficacious in relieving anginal symptoms caused by coronary vasospasm, and its value as an antiarrhythmic agent remains to be delineated.
Journal ArticleDOI
Mechanism of Action of Calcium-Channel-Blocking Agents
TL;DR: The development of drugs that interfere with the entry of Ca++ into cells has provided the basic scientist with powerful new tools for the study of the role of this ion in normal as well as pathologic states.
Journal ArticleDOI
Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.
TL;DR: Various sections of the manuscript reviewed by: U.H. Elkayam, Department of Medicine, University of Southern California, Los Angeles, California, USA, and H.R. Emanuelsson,Department of Medicine I,University of Goteborg, Gotesborg, Sweden.
Journal ArticleDOI
Nifedipine Kinetics and Bioavailability After Single Intravenous and Oral Doses in Normal Subjects
T. S. Foster,T. S. Foster,S. R. Hamann,S. R. Hamann,V. R. Richards,V. R. Richards,P. J. Bryant,P. J. Bryant,D. A. Graves,D. A. Graves,R.G. McAllister,R.G. McAllister +11 more
TL;DR: Evaluating the kinetics and bioavailability of nifedipine in 12 normal subjects after single intravenous and oral doses found profiles consistent with fast and slow absorption, with marked variability in the rate of appearance of the drug in plasma.
Journal ArticleDOI
Objective assessment of antianginal treatment: a double-blind comparison of propranolol, nifedipine, and their combination.
TL;DR: The objective methods permitted greater separation of treatment efficacy and showed reliably that the combination of propranolol and nifedipine was significantly better than either drug alone, thus this combination is a safe and effective form of treatment for angina.
References
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Immediate Effects of Intravenous Verapamil in Cardiac Arrhythmias
TL;DR: Verapamil was administered by intravenous injection to 181 patients with various cardiac arrhythmias, and conversion of paroxysmal supraventricular tachycardia to sinus rhythm was consistently achieved.
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Effects of Agents which Inhibit the Slow Channel on Sinus Node Automaticity and Atrioventricular Conduction in the Dog
Douglas P. Zipes,John C. Fischer +1 more
TL;DR: It is concluded that agents which inhibit the slow channel directly depress sinus node discharge rate and AV nodal conduction, effects of slow-channel inhibiting agents are not mediated through the activation of cholinergic discharge or inhibition of adrenergic discharge, and beta-receptor stimulation reverses these effects.
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Effect of Verapamil on the Normal Action Potential and on a Calcium Dependent Slow Response of Canine Cardiac Purkinje Fibers
TL;DR: Although verapamil did not alter the upstroke of the normal Na-dependent action potential, it did depress the plateau and prolong the action potential of fibers exposed to normal Tyrode's solution.
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Verapamil in the treatment of paroxysmal supraventricular tachycardia
TL;DR: It appears that verapamil is particularly suitable for the treatment of supraventricular tachycardias due to a circus movement as calcium antagonism is likely to be most effective in the N region of the atrioventricular node.