Journal ArticleDOI
Effect of nonenzymatic glycation on functional and structural properties of hemoglobin.
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TLDR
It is demonstrated that in the presence of H(2)O(2), HbA(1c) degrades DNA and protein more efficiently than Hb a(0) and formation of carbonyl content, an index of oxidative stress, is higher by H bA( 1c).About:
This article is published in Biophysical Chemistry.The article was published on 2005-03-01. It has received 111 citations till now. The article focuses on the topics: Glycated hemoglobin & Glycation.read more
Citations
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Journal ArticleDOI
What Is Responsible for the Initiating Chemistry of Iron-Mediated Lipid Peroxidation: An Update
Zhiyong Cheng,Yuanzong Li +1 more
Journal ArticleDOI
Raman Spectroscopy-Based Sensitive and Specific Detection of Glycated Hemoglobin
Ishan Barman,Narahara Chari Dingari,Jeon Woong Kang,Gary L. Horowitz,Ramachandra R. Dasari,Michael S. Feld +5 more
TL;DR: The potential of Raman spectroscopy as a novel analytical method for quantitative detection of HbA1c, without using external dyes or reagents is proposed and demonstrated, and the excellent accuracy and reproducibility achieved in this proof-of-concept study is demonstrated.
Journal ArticleDOI
Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats.
TL;DR: The study investigates the effect of glycyrrhizin on streptozotocin‐induced diabetic changes and associated oxidative stress, including haemoglobin‐induced free iron‐mediated oxidative reactions.
Journal ArticleDOI
Protein oxidation parameters in type 2 diabetic patients with good and poor glycaemic control
TL;DR: Increase in plasma PCO, AOPP, and LHP levels in the diabetic patients with poor glycaemic control may contribute to the development of diabetic complications.
Journal ArticleDOI
Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: implication for glycation-induced hemoglobin modification.
TL;DR: Pelargonidin counteracts hemoglobin glycation, iron release from the heme protein and iron-mediated oxidative damages, confirming glycated hemoglobin-associated oxidative stress in diabetes.
References
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Book ChapterDOI
Determination of carbonyl content in oxidatively modified proteins.
Rodney L. Levine,Donita Garland,Cynthia N. Oliver,Adolfo Amici,Isabel Climent,Anke-G. Lenz,Bong-Whan Ahn,Shmuel Shaltiel,Earl R. Stadtman +8 more
TL;DR: This chapter discusses methods to determine carbonyl content in oxidatively modified proteins and quantitated protein-bound pyruvoyl groups through formation of a Schiff base with p-aminobenzoic acid followed by reduction with cyanoborohydride.
Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion.
Journal ArticleDOI
Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.
TL;DR: The results of the model compound study provide evidence for a mechanism that follows the classical Stern-Volmer law (1919), predominantly involving collisional quenching, and illustrate the importance of local charge and solvent viscosity.
Journal ArticleDOI
DNA damage by oxygen-derived species Its mechanism and measurement in mammalian systems
Barry Halliwell,Okezie I. Aruoma +1 more
TL;DR: Observation of the role of different oxygen‐derived species in DNA cleavage reactions has been used to determine the extent of oxidative damage to DNA in vivo and to investigate the mechanism of DNA damage by ionizing radiation and chemical carcinogens.