Journal ArticleDOI
Effect of Prolonged Chlorpromazine Administration on the Sleep of Chronic Schizophrenics
TLDR
Sleep latency and awake time were significantly decreased on chlorpromazine while stage II, delta sleep, delta%, nonrapid eye movement (NREM) sleep, REM activity, REM latency, and REM density were significantly increased.Abstract:
The sleep of 13 chronic male schizophrenics was studied during a one-month trial of chlorpromazine and compared with one-month placebo periods. Electroencephalographic recordings were made only after the patients had been on chlorpromazine hydrochloride or a placebo for at least three weeks. Sleep latency and awake time were significantly decreased on chlorpromazine while stage II, delta sleep, delta%, nonrapid eye movement (NREM) sleep, REM activity, REM latency, and REM density were significantly increased. There were no significant changes in REM time, REM%, stage II%, and NREM%.read more
Citations
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Journal ArticleDOI
Sleep and Psychiatric Disorders: A Meta-analysis
TL;DR: Although no single sleep variable appeared to have absolute specificity for any particular psychiatric disorder, patterns of sleep disturbances associated with categories of psychiatric illnesses were observed.
Journal ArticleDOI
Sleep disturbances in patients with schizophrenia : impact and effect of antipsychotics.
TL;DR: It appears possible that the high-potency drugs exert their effects on sleep in schizophrenic patients, for the most part, in an indirect way by suppressing stressful psychotic symptomatology.
Journal ArticleDOI
Drug effects on REM sleep and on endogenous depression
TL;DR: The present study reviewed literature from 1962 to 1989 on drug REM sleep effects to examine the hypothesis that drugs producing arousal-type RSD improve endogenous depression, and indicated that all drugs producing arousing RSD improved endogenous depression.
Journal ArticleDOI
Electroencephalographic sleep abnormalities in schizophrenia. Relationship to positive/negative symptoms and prior neuroleptic treatment.
Rajiv Tandon,James E. Shipley,Stephan F. Taylor,John F. Greden,Alan S. Eiser,John R. DeQuardo,JoAnn Goodson +6 more
TL;DR: Electroencephalographic sleep in drug-naive and previously medicated schizophrenics had significantly greater impairment of sleep continuity and shorter rapid eye movement latency when compared with controls, and findings were significantly influenced by duration of drug-free status.
Journal ArticleDOI
Sleep-promoting properties of quetiapine in healthy subjects
Stefan Cohrs,Andrea Rodenbeck,Zhenghua Guan,Kathrin Pohlmann,Wolfgang Jordan,Andreas Meier,Eckart Rüther +6 more
TL;DR: The sleep-improving properties of quetiapine may be important in counteracting different aspects of psychopathology in schizophrenia and other disorders and other mechanisms might be relevant as well and further investigation is required.
References
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Journal Article
Growth hormone secretion during sleep
TL;DR: In this paper, growth hormone (GH), insulin, cortisol, and glucose were measured during sleep on 38 nights in eight young adults, and the effects of 6-CNS-active drugs on sleep-related GH secretion were investigated.
Journal ArticleDOI
Growth hormone secretion during sleep
TL;DR: Altered hypothalamic activity associated with initiation of sleep results in a major peak of growth hormone secretion unrelated to hypoglycemia or changes in cortisol and insulin secretion.
Journal ArticleDOI
EEG sleep patterns as a function of normal and pathological aging in man
Irwin Feinberg,Irwin Feinberg,Richard L. Koresko,Richard L. Koresko,Naomi Heller,Naomi Heller +5 more
TL;DR: It appears that the EEG of sleep may prove to be a diagnostic and research tool of special value to geriatric psychiatry because the quantitative changes in sleep with normal and pathological aging are similar to changes which take place in rate of overall brain metabolism.
Journal ArticleDOI
The effects of precursor loading in the cerebral metabolism of 5‐hydroxyindoles
A. T. B. Moir,D. Eccleston +1 more
TL;DR: It is concluded that there are regional differences within brain in storage, turnover or metabolic fate of 5‐HT, and that turnover through the system is normally controlled by intracerebral tryptophan 5‐hydroxylase in both rats and dogs although there are differences between the species in the cerebral metabolism of5‐HT.
Journal ArticleDOI
dl‐5‐Hydroxytryptophan‐induced changes in central monoamine neurons after peripheral decarboxylase inhibition*
TL;DR: The ability of the 5‐ HT neurons to take up and accumulate 5‐HT in the presence of5‐HTP is relatively low in spite of large amounts of 5-HTP present in the brain neuropil after extracerebral decarboxylase inhibition.