Effect of Withania somnifera (Ashwagandha) on the Development of Chemotherapy-Induced Fatigue and Quality of Life in Breast Cancer Patients:
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TLDR
Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life, however, further study with a larger sample size in a randomized trial is warranted to validate the findings.Abstract:
Hypothesis. Withania somnifera is an herb with antioxidant, anti-inflammatory, anticancer, antistress, and adaptogenic properties. Previous studies have shown its antistress effects in animals. Tra...read more
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Cancer therapy with phytochemicals: evidence from clinical studies.
Azar Hosseini,Ahmad Ghorbani +1 more
TL;DR: Curcumin, green tea, resveratrol and Viscum album were the satisfactory instances of clinical evidence for supporting their anticancer effects, and the main findings of these phytochemicals were summarized and discussed.
Journal ArticleDOI
Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone
Avani R. Vyas,Shivendra V. Singh +1 more
TL;DR: Cancer-protective role for WA has now been established using chemically-induced and oncogene-driven rodent cancer models, and key in vivo preclinical studies demonstrating anticancer effects of WA are summarized.
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Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
TL;DR: A comprehensive review of the properties of WS extracts (WSE) containing complex mixtures of diverse components including WFA, which have shown inhibitory properties against many cancers, along with their mechanism of actions and pathways involved.
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Anticancer activities of Withania somnifera: Current research, formulations, and future perspectives
TL;DR: This review provides a detail account of its vital phytoconstituents and summarizes the present status of the research carried out on its anticancerous activities, giving future directions.
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Withania somnifera: From prevention to treatment of cancer
TL;DR: The traditional uses of Withania somnifera, the experimental evidence supporting its chemopreventive potential as well as roadblocks that need to be overcome in order for WS to be evaluated as a chemop reventive agent in humans are discussed.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal Article
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
TL;DR: Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity, indicating this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects.
Journal Article
The revised Piper Fatigue Scale: psychometric evaluation in women with breast cancer.
Barbara F. Piper,Suzanne L. Dibble,Marylin J. Dodd,Marisa C. Weiss,Robert E. Slaughter,Steven M. Paul +5 more
TL;DR: The revised version of the Piper Fatigue Scale consists of 22 items and four subscales: behavioral/severity (6 items), affective meaning (5 items), sensory(5 items) and cognitive/mood (6Items) and standardized alpha for the entire scale is 0.97, indicating that some redundancy may exist among the items.
Journal ArticleDOI
Cancer-related fatigue: A critical appraisal
TL;DR: Accumulation of cancer-related fatigue is apparent both during and after anti-cancer therapy, however, the prevalence of CRF varied between studies.