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Journal ArticleDOI

Effect of Withania somnifera on Lysosomal Acid Hydrolases in Adjuvant‐induced Arthritis in Rats

01 Apr 2000-Pharmacy and Pharmacology Communications (PHARMACY AND PHARMACOLOGY COMMUNICATIONS)-Vol. 6, Iss: 4, pp 187-190
TL;DR: Results indicate that Withania somnifera has promising anti-arthritic activity as a result of its stabilizing action on lysosomal enzyme activity.
Abstract: The effect of Withania somnifera Linn. Dunal (Solanaceae) on adjuvant arthritic rats was studied and compared with that of indomethacin. These results indicate that Withania somnifera has promising anti-arthritic activity as a result of its stabilizing action on lysosomal enzyme activity. The anti-inflammatory activity of Withania somnifera was assessed by measuring paw swelling and lysosomal enzyme activity in control and experimental rats. Increased paw diameter and lysosomal enzyme activity in the arthritic animals were significantly suppressed to near normal levels in rats treated with 1000 mg kg−1Withania somnifera root powder and 3 mg kg−1 indomethacin.
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Journal ArticleDOI
TL;DR: The aqueous suspension of Withania somnifera root powder showed potent inhibitory activity towards the complement system, mitogen induced lymphocyte proliferation and delayed-type hypersensitivity reaction, thus it could be a candidate for developing as an immunosuppressive drug for the inflammatory diseases.

175 citations

Journal ArticleDOI
TL;DR: Evidence is provided for the suppressive effect of W. somnifera root powder by retarding amplification and propagation of the inflammatory response without causing any gastric damage.

90 citations

Journal ArticleDOI
TL;DR: The results obtained clearly indicate the fact that the Indian Ayurvedic herbal formulation Triphala has promising antiinflammatory activity.
Abstract: In the present study, attempts have been made to evaluate the antiarthritic effect of the Indian Ayurvedic herbal formulation Triphala on adjuvant-induced arthritis in mice and to compare it with that of the non-steroidal antiinflammatory drug indomethacin. Arthritis was induced by intradermal injection of complete Freund's adjuvant (0.1 mL) into the right hind paw of Swiss albino mice. Triphala (1 g/kg/bxwt) and indomethacin (3 mg/kg/bxwt) were administered orally for 8 days (from day 11 to 18) after adjuvant injection. The levels of lysosomal enzymes, tissue marker enzymes, glycoproteins and paw thickness were increased in adjuvant-induced arthritic animals. The body weight was found to be reduced when compared with the control animals. These physical and biochemical changes observed in arthritic animals were altered significantly to near normal conditions after oral administration of Triphala (1 g/kg/bxwt). The results obtained clearly indicate the fact that the Indian Ayurvedic herbal formulation Triphala has promising antiinflammatory activity.

80 citations

Journal ArticleDOI
TL;DR: The results of this study clearly indicate that W. somnifera root powder is capable of rectifying the above biochemical changes in adjuvant arthritis.
Abstract: The present investigation was carried out to evaluate the protective effect of Withania somnifera Linn. Dunal (family-Solanaceae), commonly known as Ashwagandha, on adjuvant-induced arthritic rats. Results were compared with those for Indomethacin, a nonsteroidal anti-inflammatory drug. Arthritis was induced by intradermal injection of complete Freund's adjuvant (0.1 mL) into the right hind paw of Wistar albino rats. Withania somnifera root powder (1000 mg/kg/day) and Indomethacin (3 mg/kg/day) were orally administered for 8 days (from 11th to 18th day) after adjuvant injection. The anti-arthritic effect of W. somnifera root powder was assessed by measuring changes in lipid peroxidation, antioxidant status, and glycoprotein levels in plasma and spleen of arthritic animals. In addition, cartilage degradation was also assessed by estimating bone collagen, and urinary constituents in arthritic animals. Results of the present investigation showed significant increase in the level of lipid peroxides, glycoproteins, and urinary constituents with the depletion of antioxidant status and bone collagen in arthritic animals. These biochemical alterations observed were ameliorated significantly by oral administration of W. somnifera root powder (1000 mg/kg body weight) in arthritic animals. The results of this study clearly indicate that W. somnifera root powder is capable of rectifying the above biochemical changes in adjuvant arthritis.

76 citations

Journal ArticleDOI
TL;DR: Administration of W. somnifera root powder to the arthritic rats significantly decreased the severity of arthritis by effectively suppressing the symptoms of arthritis and improving the functional recovery of motor activity and radiological score.
Abstract: Context: Withania somnifera (Linn) Dunal (Solanaceae) has long been used as an herb in Ayurvedic and indigenous medicine and has received intense attention in recent years for its chemopreventive propertiesObjective: The present study focuses on the effect of W somnifera root powder on the behavioral and radiological changes in collagen-induced arthritic ratsMaterials and methods: The rats were randomly divided into five groups: normal control, arthritic control, arthritic rats treated with W somnifera root powder (at dose levels 600 and 800 mg kg−1) and arthritic rats treated with methotrexate (at dose level 03 mg kg−1) The treatment with W somnifera (daily) and methotrexate (weekly) was initiated from the 20th day post collagen immunization and continued up until the 45th day Arthritis was assessed macroscopically by measuring paw thickness, ankle size and body weight Arthritic pain was assessed by toe-spread and total print length of the affected paw Functional recovery due to the or

74 citations


Cites background from "Effect of Withania somnifera on Lys..."

  • ...Rasool et al. (2000) and Rasool and Varalakshmi (2006), by using the adjuvant induced arthritic rat model, have also demonstrated the immunomodulatory role and antiinflammatory activity of W. somnifera roots....

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