Journal ArticleDOI
Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study.
TLDR
The aqueous suspension of Withania somnifera root powder showed potent inhibitory activity towards the complement system, mitogen induced lymphocyte proliferation and delayed-type hypersensitivity reaction, thus it could be a candidate for developing as an immunosuppressive drug for the inflammatory diseases.About:
This article is published in Vascular Pharmacology.The article was published on 2006-06-01. It has received 175 citations till now. The article focuses on the topics: Withania somnifera & Withania.read more
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Oxidative Stress, Prooxidants, and Antioxidants: The Interplay
Anu Rahal,Amit Kumar,Vivek Singh,Brijesh Yadav,Ruchi Tiwari,Sandip Chakraborty,Kuldeep Dhama +6 more
TL;DR: The importance of oxidative stress in the body growth and development as well as proteomic and genomic evidences of its relationship with disease development, incidence of malignancies and autoimmune disorders, increased susceptibility to bacterial, viral, and parasitic diseases are discussed.
Journal ArticleDOI
Withaferin A Causes FOXO3a- and Bim-Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In vivo
TL;DR: The WA treatment decreased viability of MCF-7 and MDA-MB-231 human breast cancer cells in a concentration-dependent manner and pointed toward an important role of FOXO3a and Bim in regulation of WA-mediated apoptosis in human breast cancers.
Journal ArticleDOI
The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from indian winter cherry
TL;DR: Results demonstrate that the tumor proteasome β5 subunit is the primary target of Withaferin A, and inhibition of the proteasomal chymotrypsin-like activity by WA in vivo is responsible for, or contributes to, the antitumor effect of this ancient medicinal compound.
Journal ArticleDOI
Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species.
Eun-Ryeong Hahm,Michelle Barbi de Moura,Eric E. Kelley,Bennett Van Houten,Sruti Shiva,Shivendra V. Singh +5 more
TL;DR: It is demonstrated, for the first time, that WA-induced apoptosis is mediated by reactive oxygen species (ROS) production due to inhibition of mitochondrial respiration and ROS production resulting from WA exposure was accompanied by inhibition of oxidative phosphorylation and inhibition of complex III activity.
Journal ArticleDOI
Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis
TL;DR: Withaferin-A (WA) is a bioactive compound derived from Withania somnifera, which inhibits Notch-1 signaling and downregulates prosurvival pathways, such as Akt/NF-κB/Bcl-2, in three colon cancer cell lines.
References
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Journal ArticleDOI
Studies on the immunomodulatory effects of Ashwagandha.
TL;DR: Treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes, which prevented myelosuppression in mice treated with all three immunosuppressive drugs tested.
Journal ArticleDOI
Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation.
TL;DR: The immunomodulatory activities of an Indian Ayurvedic medicinal preparation, i.e. WST and WS2, were studied in mice for immune inflammation: active paw anaphylaxis and delayed type hypersensitivity (DTH), revealing a significant increase in white blood cell counts and platelet counts.
Book
Immunology, immunopathology, and immunity
TL;DR: This book discusses the interplay of Inflammatory and Immunopathologic Mechanisms, Immune Defense, and Evasion of Immunedefense Mechanisms during Infection, and the history of Immunopathology.