Effects of Adenosine Compounds on Renal Function and Renin Secretion in Dogs
Hitoshi Tagawa,Arthur J. Vander +1 more
TLDR
It is suggested that adenosine or 5′-AMP may be normal mediators of both autoregulation and renin secretion in anesthetized salt-depleted dogs.Abstract:
In anesthetized salt-depleted dogs, infusion of adenosine (20 to 500 µg/min) directly into a renal artery induced an initial decrease of renal blood flow for 1 to 2 minutes but did not change or slightly increased this flow during the steady state. Statistically significant decreases occurred in glomerular filtration rate, filtration fraction, sodium excretion, and renal venous renin activity. Calculated afferent arteriolar resistance increased and efferent resistance decreased. 5'-AMP (50 to 200 µg/min) induced changes which were smaller but qualitatively similar to those of adenosine. ATP (50 to 500 µg/min) induced no initial reduction in blood flow, and, during the steady state, caused a significant increase in blood flow and decreases in glomerular filtration rate, filtration fraction, sodium excretion, and renal venous renin. Efferent resistance decreased but afferent resistance did not change. Cyclic AMP (1 to 5 mg/min) caused a very small initial transient reduction in blood flow but induced change...read more
Citations
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The Renin-Angiotensin System
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TL;DR: Through these actions, the renin-angiotensin system plays an im portant role in the regulation of blood pressure and of the volume and composition of the extracellular fluid.
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Cellular distribution and functions of P2 receptor subtypes in different systems.
TL;DR: This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body.
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Are methylxanthine effects due to antagonism of endogenous adenosine
TL;DR: Some of the increasing evidence that adenosine may be physiological modulator of several biological functions and that theophylline in low doses antagonizes the actions of this purine nucleoside are presented.
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Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors
Daqing Sun,Linda C. Samuelson,Tianxin Yang,Yuning Huang,Alex Paliege,Thom Saunders,Josie P. Briggs,Jurgen Schnermann +7 more
TL;DR: A1AR null mutant mice are a promising tool to study the functional role of A1AR in different target tissues and suggest that adenosine is a required constituent of the juxtaglomerular signaling pathway.
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Adenosine and Kidney Function
TL;DR: Differential effects of adenosine tonically inhibits the renal release of renin and stimulates NaCl transport in the cortical proximal tubule but inhibits it in medullary segments including theMedullary thick ascending limb.
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