Journal ArticleDOI
Efficacy and safety of a fixed combination of travoprost 0.004%/timolol 0.5% ophthalmic solution once daily for open-angle glaucoma or ocular hypertension.
Joel S. Schuman,Gregory J. Katz,Richard A. Lewis,J. Charles Henry,Sushanta Mallick,David T. Wells,E. Kenneth Sullivan,Theresa A. Landry,Michael V.W. Bergamini,Stella M. Robertson +9 more
TLDR
It is demonstrated that the fixed combination of travoprost/timolol produces significant and clinically relevant reductions of IOP in a once-daily dosing regimen, and reductions that were similar to concomitant traVoprost + timolol.About:
This article is published in American Journal of Ophthalmology.The article was published on 2005-08-01. It has received 97 citations till now. The article focuses on the topics: Timolol & Travoprost.read more
Citations
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Journal ArticleDOI
Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
TL;DR: Lowering intraocular pressure is still the mainstay for glaucoma treatment but neuroprotective drugs represent a promising next-generation therapy and future therapeutic opportunities are highlighted.
Journal ArticleDOI
The side effects of the prostaglandin analogues
TL;DR: The systemic side-effect profile is favourable for all the prostaglandin analogues, and some of the local side effects are only of cosmetic significance.
Journal ArticleDOI
Considerations in glaucoma therapy: fixed combinations versus their component medications.
TL;DR: Comparing the efficacy and tolerability of FCDT and FCBT in the management of glaucoma and ocular hypertension suggests that FCBT is at least as effective as FCDt in lowering IOP and is more comfortable and better tolerated.
Journal ArticleDOI
Fixed-dose combination of AR-13324 and latanoprost: a double-masked, 28-day, randomised, controlled study in patients with open-angle glaucoma or ocular hypertension
TL;DR: In this short-term study, the fixed-dose combination of AR-13324 0.02% and latanoprost 0.005% in PG324 Ophthalmic Solution provides clinically and statistically superior ocular hypotensive efficacy relative to its individual active components at the same concentrations.
Journal ArticleDOI
Use of Fixed-Dose Combination Drugs for the Treatment of Glaucoma
TL;DR: Fixed combination treatments for glaucoma offer effective IOP control while reducing the washout effect and exposure to preservatives, and are also convenient.
References
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Journal ArticleDOI
The Ocular Hypertension Treatment Study: A Randomized Trial Determines That Topical Ocular Hypotensive Medication Delays or Prevents the Onset of Primary Open-Angle Glaucoma
Michael A. Kass,Dale K. Heuer,Eve J. Higginbotham,Chris A. Johnson,John L. Keltner,J. Philip Miller,Richard K. Parrish,M. Roy Wilson,Mae O. Gordon +8 more
TL;DR: Topical ocular hypotensive medication was effective in delaying or preventing the onset of POAG in individuals with elevated IOP, and clinicians should consider initiating treatment for individuals with ocular hypertension who are at moderate or high risk for developing POAG.
Journal ArticleDOI
The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deterioration
Fred Ederer,Ma,Douglas E. Gaasterland,E. Kenneth Sullivan,Allen D. Beck,Bruce E. Prum,Marshall N. Cyrlin,Howard S. Weiss +7 more
TL;DR: In both analyses low intraocular pressure is associated with reduced progression of visual field defect, supporting evidence from earlier studies of a protective role for low intracular pressure in visual field deterioration.
Journal ArticleDOI
Open-Angle Glaucoma
TL;DR: This review concentrates on primary open-angle glaucoma, the most prevalent form of the disorder in Western countries, and the present standard for determining visual loss.
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The ocular hypertension treatment study.
TL;DR: To determine if there is a penalty for delaying treatment, the cumulative proportions of participants who developed POAG at a median follow-up of 13 years in the original observation group and the original medication group were compared.
Journal Article
Overview of patient compliance with medication dosing: a literature review.
TL;DR: Once- a-day and twice-a-day regimens were associated with significantly better compliance than were three- times-daily and four-times-daily regimens.