Journal ArticleDOI
Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction
M. J. Janse,A. L. Wit +1 more
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This article is published in Physiological Reviews.The article was published on 1989-10-01. It has received 985 citations till now. The article focuses on the topics: Electrocardiography in myocardial infarction & Myocardial infarction complications.read more
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Molecular Mechanisms of Myocardial Remodeling
TL;DR: This review focuses only on permanent modifications in relation to clinical dysfunction in cardiac remodeling secondary to myocardial infarction and/or arterial hypertension and includes a special section on the senescent heart, since CR is mainly a disease of the elderly.
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Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT
Desmond G. Julian,A. J. Camm,G. Frangin,Michiel J. Janse,A. Munoz,Peter J. Schwartz,P. Simon +6 more
TL;DR: The findings do not support the systematic prophylactic use of amiodarone in all patients with depressed left-ventricular function after myocardial infarction, but the lack of proarrhythmia and the reduction in arrhythmic death support the use of the drug in patients for whom antiarrhythmmic therapy is indicated.
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Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias
André G. Kléber,Yoram Rudy +1 more
TL;DR: This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart.
Journal ArticleDOI
Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation
TL;DR: The changes in ion channel and transporter properties associated with three important clinical and experimental paradigms: congestive heart failure, myocardial infarction, and atrial fibrillation are reviewed and important opportunities for improved therapeutic approaches are highlighted.
Journal ArticleDOI
Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.
Charles Antzelevitch,Serge Sicouri,Silvio H. Litovsky,Anton Lukas,S C Krishnan,J. M. Di Diego,G. A. Gintant,Da-Wei Liu +7 more
TL;DR: In spite of important advances in cardiology in recent years, pharmacological control of cardiac arrhythmias in the clinic remains an experiment conducted on a patient-by-patient basis using a trial and error approach tempered by good clinical judgment.