Electrophysiological Properties of the Canine Peripheral A-V Conducting System
TLDR
It was demonstrated that appropriately timed premature impulses could be confined within conducting tissue either proximal or distal to the area of maximum action potential duration.Abstract:
Action potential durations and local refractory periods were mapped along the course of canine conducting tissue from bundle branches to the termination of false tendons in ventricular muscle. Standard microelectrode techniques were used. Areas of maximum action potential duration, which coincided with areas of maximum local refractory periods, were consistently found 2 to 3 mm proximal to the termination of conducting fibers in muscle. The refractory periods at the areas of maximum action potential duration were quantitatively identical in the multiple false tendons of a segment of the conducting system, providing a uniform functional limit for the propagation of premature impulses across the distal end of the conducting system of the segments studied. It was demonstrated that appropriately timed premature impulses could be confined within conducting tissue either proximal or distal to the area of maximum action potential duration. This occurred when the area of maximum duration was still refractory, after other areas of the conducting system had recovered excitability. In most preparations, maximum action potential durations and functional refractory periods across distal false tendons were longer in tissue from the right side than from the left side of the conducting system.read more
Citations
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Journal ArticleDOI
Isolated conduction within the left His-Purkenje system during sinus rhythm and idiopathic left ventricle tachycardia: findings from mapping the whole conduction system.
De-Yong Long,Jian-Zeng Dong,Cai-Hua Sang,Chen-Xi Jiang,Ri-Bo Tang,Qian Yan,Rong-Hui Yu,Song-Nan Li,Yan Yao,Man Ning,Tao Lin,Mohamed Salim,Xin Du,Changsheng Ma +13 more
TL;DR: In this paper, the authors investigated the gross anatomy of the left His-Purkenje system (HPS) during sinus rhythm (SR) and idiopathic left ventricle tachycardia (ILVT) and found that isolated conduction within the HPS is demonstrated by documenting the reverse activation sequence with its surrounding myocardium.
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The Gating Mechanism in the Distal Atrioventricular Conducting System
TL;DR: Recording of transmembrane action potentials from single cells with intracellular microelectrodes has shown that the refractory period of individual cells after a depolarization is primarily related to the duration of the action potential.
Journal ArticleDOI
A slowly inactivating sodium current (INa2) in the plateau range in canine cardiac Purkinje single cells
TL;DR: Purkinje cells have a slowly decaying inward current owing to Na+ entry (INa2) that is different in several ways from the fast INa1 and that appears important for the duration of the plateau.
Journal ArticleDOI
The electrical activity of the bundle of His. The fast and slow inward currents.
TL;DR: The present results indicate that both the fast and the slow inward currents participate in the generation of the action potentials of the bundle of His, and the proportion of each current varies, depending on the segment of the bundles in which theaction potentials were originated.
References
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Journal ArticleDOI
Temporal dispersion of recovery of excitability in atrium and ventricle as a function of heart rate.
TL;DR: It was concluded that spontaneous closely coupled beats occurring at slow ventricular rates in A-V dissociation may result from asynchrony in the repolarization of adjacent excitable units.
Journal ArticleDOI
Der Aktionsstrom der Myokardfaser im Sauerstoffmangel
TL;DR: In this paper, the Herzmuskel noch vom Skeletmnskel durch seine wesentlich größere Empfindlichkeit gegen Sauerstoffmangel.
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The action current of the myocardial fibers in oxygen deficiency
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