Electrophysiological Properties of the Canine Peripheral A-V Conducting System
TLDR
It was demonstrated that appropriately timed premature impulses could be confined within conducting tissue either proximal or distal to the area of maximum action potential duration.Abstract:
Action potential durations and local refractory periods were mapped along the course of canine conducting tissue from bundle branches to the termination of false tendons in ventricular muscle. Standard microelectrode techniques were used. Areas of maximum action potential duration, which coincided with areas of maximum local refractory periods, were consistently found 2 to 3 mm proximal to the termination of conducting fibers in muscle. The refractory periods at the areas of maximum action potential duration were quantitatively identical in the multiple false tendons of a segment of the conducting system, providing a uniform functional limit for the propagation of premature impulses across the distal end of the conducting system of the segments studied. It was demonstrated that appropriately timed premature impulses could be confined within conducting tissue either proximal or distal to the area of maximum action potential duration. This occurred when the area of maximum duration was still refractory, after other areas of the conducting system had recovered excitability. In most preparations, maximum action potential durations and functional refractory periods across distal false tendons were longer in tissue from the right side than from the left side of the conducting system.read more
Citations
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Purkinje and ventricular activation sequences of canine papillary muscle. Effects of quinidine and calcium on the Purkinje-ventricular conduction delay.
TL;DR: In vitro preparations of canine right and left papillary muscles are studied to determine the excitation sequences of the Purkinje and ventricular cells, using both monopolar surface electrodes and intracellular microelectrodes to show that thePurkinje layer covers the basal part of the muscle, and that activation from the right bundle branch propagates over all of the purkinjelayer, but directly activates the underlying ventricular layer only at specific junctional sites.
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Anatomical and molecular mapping of the left and right ventricular His-Purkinje conduction networks.
Andrew Atkinson,Shin Inada,Jue Li,James O. Tellez,Joseph Yanni,R.N. Sleiman,Eman S.H. Abd Allah,Robert H. Anderson,Henggui Zhang,Mark R. Boyett,Halina Dobrzynski +10 more
TL;DR: The His-Purkinje network in the left ventricle is more developed than that in the right ventricles and this may explain its greater clinical importance, as well as the specialised electrical activity of the Purkinje fibres as suggested by computer simulations.
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TL;DR: Primary idiopathic ventricular fibrillation is a syndrome characterized by dominant triggers from the distal Purkinje system that can be eliminated by focal energy delivery.
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Conduction Disturbances Located within the His Bundle
TL;DR: Impulse conduction through the A-V node was normal in all four cases, as could be concluded from the effect of increased atrial driving rate and of accurately timed atrial premature beats.
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Effect of an Early Atrial Premature Beat on Activity of the Sinoatrial Node and Atrial Rhythm in the Rabbit
TL;DR: The results of the experiments led to the conclusion that the impulse of the premature beat, elicited early in the atrial cycle, discharges the SA node only fractionally and that the fibers in the neighborhood of the activated area are influenced electrotonically.
References
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Journal ArticleDOI
Temporal dispersion of recovery of excitability in atrium and ventricle as a function of heart rate.
TL;DR: It was concluded that spontaneous closely coupled beats occurring at slow ventricular rates in A-V dissociation may result from asynchrony in the repolarization of adjacent excitable units.
Journal ArticleDOI
Der Aktionsstrom der Myokardfaser im Sauerstoffmangel
TL;DR: In this paper, the Herzmuskel noch vom Skeletmnskel durch seine wesentlich größere Empfindlichkeit gegen Sauerstoffmangel.
Journal ArticleDOI
The action current of the myocardial fibers in oxygen deficiency
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