Journal ArticleDOI
Enhancement of imipramine by thyroid stimulating hormone: clinical and theoretical implications.
TLDR
Thyroid stimulating hormone, when combined with imipramine, produces a more rapid recovery from depression than does imipramsine alone, but dose differences prevent accurate comparison.Abstract:
Thyroid stimulating hormone, when combined with imipramine, produces a more rapid recovery from depression than does imipramine alone. It seems more potent than triiodothyronine in potentiating imipramine, but dose differences prevent accurate comparison. This hormone has the clinical disadvantage of being long acting and difficult to control. Depressed patients show thyroid indices within the normal range. Serum indices of thyroid state respond normally to TSH injection, but ankle reflex time is not accelerated. Tantalizing clues have appeared, but the mechanism by which thyroid hormones potentiate tricyclic antidepressants remains unknown.read more
Citations
More filters
Journal ArticleDOI
Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression
TL;DR: The effects of long-term antidepressant treatment on biogenic amine metabolism and on various indexes of presynaptic and postsynaptic receptor function are evaluated to provide support for hypotheses of amine receptor abnormalities in depression and indicate the need for expanded studies ofAmine receptor function in patients.
Journal ArticleDOI
Effects of thyrotropin-releasing hormone in depression.
TL;DR: Ten euthyroid women with unipolar depression were treated with a single injection of thyrotropin-releasing hormone (T.R.H.) and a single injections of saline in a double-blind, crossover comparison to cause a prompt, brief improvement in depression.
Journal ArticleDOI
Depressive Disorders: Toward a Unified Hypothesis
TL;DR: This work has attempted to demonstrate that the animal models simulate some of the central features of clinical depression (for example, helplessness and object loss), thereby allowing one to rigorously investigate them from developmental, behavioral, and biochemical perspectives.
Journal ArticleDOI
A Hypothesis of Thyroid-Catecholamine-Receptor Interaction: Its Relevance to Affective Illness
TL;DR: Evidence suggests that the modulation by thyroid hormones of the beta-adrenergic receptor response to catecholamines may contribute to these effects of depression and mania.
Journal ArticleDOI
Thyrotropin releasing hormone: enhancement of dopa activity by a hypothalamic hormone.
TL;DR: Thyrotropin releasing hormone potentiates the behaviorial effects of dopa plus pargyline in mice as well as in normal mice, and the phenomenon is independent of the release of thyroid stimulating hormone from the pituitary.
References
More filters
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal ArticleDOI
A self-rating depression scale.
TL;DR: The general depression scales used were felt to be insufficient for the purpose of this research project and the more specific scales were also inadequate.
Journal ArticleDOI
Inhibition of uptake of tritiated-noradrenaline in the intact rat brain by imipramine and structurally related compounds.
Jacques Glowinski,Julius Axelrod +1 more
TL;DR: A procedure which made it possible to introduce tritiated-noradrenaline of high specific activity into the rat brain by an intraventricular injection is described and it will be shown that imipramine and structurally related antidepressant drugs but not chlorpromazine block the uptake of tritiates in the brain.
Journal ArticleDOI
Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone
TL;DR: Twenty euthyroid patients with retarded depression were studied to determine the possible role of alterations in thyroid function in the etiology and treatment of depression, and T3 was physiologically active, altering protein-bound iodine values and accelerating ankle reflex time.