Journal ArticleDOI
Enzymic reduction of aromatic hydrocarbon epoxides by the microsomal fraction of rat liver.
TLDR
Preliminary investigations suggest that the enzyme concerned in the reduction of these epoxides is specific for both 'K-region' and 'non-K- Region' arene oxides.Abstract:
1. The oxidation of aromatic hydrocarbons to arene oxides and the reduction of these oxides to the parent hydrocarbons are both catalysed by enzymes in the microsomal fraction of rat liver. A suggested name for the enzyme concerned in the reduction of these epoxides is 'epoxide reductase'.2. 'Epoxide reductase' is NADPH-dependent and is inhibited by oxygen.3. Preliminary investigations suggest that the enzyme is specific for both 'K-region' and 'non-K-region' arene oxides.read more
Citations
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Book ChapterDOI
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.
TL;DR: The knowledge of the way in which mutagens and carcinogens are metabolized is essential to a better understanding of their mode of action and of the processes for their detoxication.
Journal ArticleDOI
The Ah locus: genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cytochrome P-450-mediated monooxygenases.
Nebert Dw,Jensen Nm +1 more
TL;DR: The Ah Locus: Genetic Regulation of the Metabolism of Carcinogens, Drugs, and Other Environmental Chemicals by Cytochrome P-450-Mediated Monooxygenase as mentioned in this paper.
Book ChapterDOI
Enzymes involved in the metabolism of plant allelochemicals
TL;DR: This chapter provides an account of a complex of several enzymes which together spare few ingested plant chemicals from being transformed into one or more metabolites which may be utilized or eliminated.
Journal ArticleDOI
Cytosolic epoxide hydrolase.
Johan Meijer,Joseph W. DePierre +1 more
TL;DR: Observations indicate that this enzyme may actually be localized in peroxisomes in vivo and is recovered in the high-speed supernatant because of fragmentation of these fragile organelles during homogenization, and the functional significance of cytosolic epoxide hydrolase is still largely unknown.
References
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Journal ArticleDOI
Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide
TL;DR: It is suggested that epoxides are the important reactive metabolites responsible for the biological effects of these carcinogens4.
Journal ArticleDOI
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
TL;DR: Whether a given aromatic or olefinic compound produces such an effect would depend on a variety of factors, such as the relative rate of formation and degradation of the intermediate oxirane, on its stability with respect to spontaneous isomerization to the corresponding phenol and on its chemical electrophilic reactivity.
Journal ArticleDOI
1,2-naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene.
Journal ArticleDOI
A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide☆
TL;DR: The simplicity of the present assay permits the use of epoxide hydrase a a marker enzyme for microsomal membranes in hepatic microsomes increases during maturation of rats and following pretreatment of rats with phenobarbital or 3-methylcholanthrene.
Journal ArticleDOI
Ultraviolet Spectra of Aromatic Compounds
Robert A. Friedel,Milton Orchin +1 more
TL;DR: Friedel and Orchin this paper published a compilation of the absorption spectra of 579 compounds, partly hydrocarbons and party non-hydrocarbons, all in the general category of aromatic compounds, in the form of graphs of log molar extinction coefficient (molar absorptivity) versus wavelength in angstroms.
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