Journal ArticleDOI
Epidemiological Observations on bovine viral diarrhea‐mucosal disease virus‐induced congenital cerebellar hypoplasia and ocular defects in calves
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Clinical and serological evidence linked the virus infection with the anomalies andCongenital cerebellar hypoplasia occurred in five calves in two New York State dairy herds in which bovine viral diarrhea-mucosal disease occurred while the dams were pregnant.Abstract:
Congenital cerebellar hypoplasia occurred in five calves in two New York State dairy herds in which bovine viral diarrhea-mucosal disease occurred while the dams were pregnant. Clinical and serological evidence linked the virus infection with the anomalies. The dams of the calves were estimated to have been infected between days 102 and 183 of pregnancy.read more
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Early reproductive loss due to bovinepestivirus infection
Michael McGowan,PD Kirkland +1 more
TL;DR: Bovine pestivirus infection has now been shown to be associated with significant early reproductive loss including fertilization failure, embryonic mortality and abortion.
Journal ArticleDOI
Pathogenetic studies of infection of the bovine fetus with bovine viral diarrhea virus. I. Cerebellar atrophy.
TL;DR: A cytopathogenic strain of bovine viral diarrhea virus was intravenously inoculated into 14 pregnant susceptible and two control heifers at 150 ± 1 days of gestation and cerebellar lesions consisting of leptomeningeal inflammation, necrosis of cells in the external germinal layer, focal hemorrhages and moderate to severe folial edema were seen.
Journal ArticleDOI
Congenital defects of the bovine central nervous system.
H. W. Leipold,S.M. Dennis +1 more
TL;DR: The most significant teratogenic agents causing central nervous system defects are prenatal viral infections such as bovine virus diarrhea and bluetongue viruses.
Journal ArticleDOI
Pathogenetic studies of infection of the bovine fetus with bovine viral diarrhea virus. II. Ocular lesions.
TL;DR: Twenty-three susceptible pregnant heifers were inoculated with bovine viral diarrhea virus and acute ocular lesions were seen in fetuses taken 17–21 days after inoculation of their dams, and in newborn animals focal to total retinal atrophy was seen.
Journal Article
Wesselsbron disease : a cause of congenital porencephaly and cerebellar hypoplasia in calves
TL;DR: Fifteen pregnant cows were inoculated subcutaneously and intravenously between 101-147 days of gestation with the wild-type Wesselsbron disease virus and 2 foetuses were injected directly through the uterine wall after surgical exposure of the pregnant horn.
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Journal Article
Spontaneous hepatitis and cerebellar "hypoplasia" in suckling rats due to congenital infections with rat virus.
L. Kilham,G. Margolis +1 more
Journal ArticleDOI
Cerebellar ataxia in hamsters inoculated with rat virus.
Lawrence Kilham,George Margolis +1 more
TL;DR: Preliminary studies suggest that hypoplasia is induced by the rat virus acting on the outer germinal layer of the cerebellum at a critical time in its ontogenic development.