Journal ArticleDOI
False-negative N.B.T. tests due to transient malfunction of neutrophils.
A. Rubinstein,B. Pelet +1 more
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This article is published in The Lancet.The article was published on 1973-02-17. It has received 35 citations till now. The article focuses on the topics: Transient (oscillation).read more
Citations
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Suppression of human neutrophil functions by tetracyclines.
W. L. Gabler,H. R. Creamer +1 more
TL;DR: Data presented in this study demonstrate that tetracyclines can also inhibit neutrophil-mediated RBC lysis, superoxide anion synthesis, degranulation and migration and that Ca2+ enrichment restored full function to EDTA- and TMB-8-treated cells but not to tetrACYcline-treated neutrophils.
Journal ArticleDOI
Effect of Tetracycline on the Phagocytic Function of Human Leukocytes
TL;DR: The purpose of the present study was to extend earlier investigations into the effect of tetracycline on phagocytosis of bacteria and yeast by human neutrophils to include peripheral blood leukocytes.
Journal ArticleDOI
The tetracyclines in dermatology.
Philippe Humbert,Pierre Treffel,Jean-François Chapuis,Stephane Buchet,Christian Derancourt,Pierre Agache +5 more
TL;DR: Cutaneous diseases that have been treated with tetracyclines and their antiinflammatory and immunosuppressive properties are reviewed.
Journal ArticleDOI
Effect of antimicrobial agents on human polymorphonuclear leukocyte microbicidal function.
W D Welch,D Davis,L D Thrupp +2 more
TL;DR: It is suggested that therapeutic concentrations of tetracycline, trimethoprim, and cephalothin may inhibit optimal polymorphonuclear leukocyte microbicidal function.
Journal ArticleDOI
In vivo suppression of neutrophil chemotaxis by systemically and topically administered tetracycline.
TL;DR: The results show that TCN does suppress neutrophil migration in vivo, and they provide support for an anti-inflammatory effect of TCN mediated in part by suppression of neutrophIL chemotaxis.
References
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INFECTION AND NITROBLUE-TETRAZOLIUM REDUCTION BY NEUTROPHILS: A Diagnostic Aid
TL;DR: Venous blood from healthy volunteers, patients with known bacterial disease, and patients with non-bacterial illnesses was incubated with a solution of nitroblue-tetrazolium (N.B.T.).
Journal ArticleDOI
Spontaneous in vitro reduction of nitroblue tetrazolium by neutrophils of adult patients with bacterial infection.
George Matula,Philip Y. Paterson +1 more
TL;DR: Elevated NBT responses were associated with a wide variety of infectious diseases due to classic pyogenic bacteria as well as nocardia and malarial parasites and could be induced in vitro with bacterial culture filtrates or high concentrations of endotoxin.
Journal ArticleDOI
Effect of Phenylbutazone on Phagocytosis and Intracellular Killing by Guinea Pig Polymorphonuclear Leukocytes
TL;DR: The anti-inflammatory drug phenylbutazone has been found to inhibit both engulfment and intracellular killing of E. coli by guinea pig peritoneal polymorphonuclear (PMN) leukocytes and it is suggested that H( 2)O(2) activates lysosomes and subsequently complexes with the lysOSomal enzyme, myeloperoxidase, which is a potent bactericidal agent in the phagocyte.
Journal Article
Decreased Nitroblue Tetrazolium Dye Reduction in the Phagocytes of Patients Receiving Prednisone
Denis R. Miller,Henry G. Kaplan +1 more
TL;DR: Nitroblue tetrazolium dye reduction by leukocytes of 21 patients receiving prednisone was significantly decreased, suggesting an induced defect of intracellular metabolism which may be related to known alterations of host defenses which occur in patients receiving these hormones.
Journal ArticleDOI
Nitroblue‐tetrazolium reduction by neutrophils of newborn infants in in vitro phagocytosis test
P. Cocchi,S. Mori,A. Becattini +2 more
TL;DR: Venous blood from healthy premature infants, premature infants with known bacterial infections, normal term infants and adults, was incubated in vitro with Pseudomonas aeruginosa to test for the nitroblue‐tetrazolium (NBT) reducing activity of neutrophils.
Related Papers (5)
INFECTION AND NITROBLUE-TETRAZOLIUM REDUCTION BY NEUTROPHILS: A Diagnostic Aid
Spontaneous in vitro reduction of nitroblue tetrazolium by neutrophils of adult patients with bacterial infection.
George Matula,Philip Y. Paterson +1 more